Lys-des[Arg 9 ]–Bradykinin Alters Migration and Production of Interleukin-12 in Monocyte-Derived Dendritic Cells

• Published in: American journal of respiratory cell and molecular biology Vol. 45; no. 3; pp. 542 - 549
• Main Authors: Gulliver, Rosalind, Baltic, Svetlana, Misso, Neil L., Bertram, Cornelia M., Thompson, Philip J., Fogel-Petrovic, Mirjana
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.09.2011
• Subjects: Adult; Asthma - metabolism; Bradykinin - pharmacology; Case-Control Studies; CD40 Ligand - chemistry; Cell Movement; Chemotactic Factors - metabolism; Cytokines - metabolism; Dendritic Cells - cytology; Humans; Interleukin-12 - metabolism; Kallidin - pharmacology; Ligands; Monocytes - cytology; Receptor, Bradykinin B1 - metabolism; Receptors, CCR7 - metabolism; RNA, Messenger - metabolism

This study tested the hypothesis that proinflammatory kinin peptides are involved in modulating human dendritic cell (DC) function. Inflammation is accompanied by an increased maturation of DCs and the generation of kinins, particularly Lys-des[Arg(9)]-bradykinin (Lda-BK). We assessed the role of Ld...