PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile

• Published in: Epigenomics Vol. 14; no. 17; pp. 987 - 993
• Main Authors: Suazo, José, Salamanca, Carlos, González-Hormazábal, Patricio, Cáceres-Rojas, Gabriela, Pantoja, Roberto, Leiva, Noemi, Pardo, Rosa
• Format: Journal Article
• Language: English
• Published: England 01.09.2022
• Subjects: Chile; Cleft Lip - genetics; Cleft Palate - genetics; Genotype; Humans; Phosphatidylethanolamine N-Methyltransferase - genetics; Polymorphism, Single Nucleotide; Chile; genetic variants; orofacial clefts; choline; PEMT; association

To assess the association between variants and nonsyndromic cleft lip with or without cleft palate in Chile and the effects of these variants on global DNA methylation. The authors obtained genotypes for nine variants from 247 cases and 453 controls for genotype-phenotype associations. The effect of...