Advancements in Gene-Based Therapeutic Angiogenesis for Chronic Limb-Threatening Ischemia

• Published in: Human gene therapy Vol. 36; no. 9-10; p. 787
• Main Authors: Wang, Peng, Di, Xiao, Li, Fengshi, Rong, Zhihua, Lian, Wenzhuo, Sun, Guoqiang, Liu, ChangWei, Ni, Leng
• Format: Journal Article
• Language: English
• Published: United States 01.05.2025
• Subjects: Angiogenesis; Animals; Chronic Limb-Threatening Ischemia - genetics; Chronic Limb-Threatening Ischemia - therapy; Genetic Therapy - methods; Hepatocyte Growth Factor - genetics; Humans; Ischemia - genetics; Ischemia - therapy; Lower Extremity - blood supply; Lower Extremity - pathology; Neovascularization, Physiologic - genetics; Vascular Endothelial Growth Factor A - genetics; clinical trial; gene therapy; therapeutic angiogenesis; peripheral artery disease; chronic limb-threatening ischemia

The objective of this article is to summarize the research progress and discuss the current difficulties of gene-based therapeutic angiogenesis in lower limb ischemic diseases, so as to provide new research directions for the non-invasive treatment of lower limb ischemia. The basic and clinical tria...