T-cell receptor γ: A microsatellite marker for colorectal cancer

• Published in: Annals of surgical oncology Vol. 9; no. 1; pp. 88 - 93
• Main Authors: Uthoff, Sonja M. S., Hunt, Louise E., Grant, Brooke S., Young, VyVy, Eichenberger, M. Robert, Cobbs, Gary A., Galandiuk, Susan
• Format: Journal Article
• Language: English
• Published: United States 01.01.2002
• Subjects: Adult; Age Factors; Colorectal Neoplasms - genetics; Female; Genes, T-Cell Receptor gamma; Genetic Markers; Genetic Predisposition to Disease; Genotype; Germ-Line Mutation - genetics; Germ-Line Mutation - immunology; Humans; Male; Microsatellite Repeats - genetics; Middle Aged; Receptors, Antigen, T-Cell, gamma-delta - genetics; Receptors, Antigen, T-Cell, gamma-delta - immunology

T-cell receptor gamma (TCR-gamma) is involved in maintaining host cell integrity and homeostasis of the human immune system. We hypothesize that polymorphism of the TCR-gamma complex may be involved in the pathogenesis of colorectal cancer. The microsatellite markers D7S1818 and D7S2206 located with...