Bifidobacterium longum subsp. infantis uses two different β-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides

• Published in: Glycobiology (Oxford) Vol. 22; no. 3; pp. 361 - 368
• Main Authors: Yoshida, Erina, Sakurama, Haruko, Kiyohara, Masashi, Nakajima, Masahiro, Kitaoka, Motomitsu, Ashida, Hisashi, Hirose, Junko, Katayama, Takane, Yamamoto, Kenji, Kumagai, Hidehiko
• Format: Journal Article
• Language: English
• Published: England 01.03.2012
• Subjects: Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Proteins - secretion; beta -Galactosidase; beta-Galactosidase - chemistry; beta-Galactosidase - genetics; beta-Galactosidase - metabolism; beta-Galactosidase - secretion; Bifidobacterium - enzymology; Bifidobacterium - genetics; Bifidobacterium - metabolism; Bifidobacterium longum; Breast milk; Carbohydrate Conformation; Carbohydrate Sequence; Carbon sources; Coevolution; Conservation; Gene Expression; Genomes; Humans; Hydrolysis; Infants; Intestine; Isomers; Lactose; Metabolism; Milk, Human - metabolism; Molecular Sequence Data; Multigene Family; oligosaccharides; Oligosaccharides - chemistry; Oligosaccharides - metabolism; Phylogeny; Substrate Specificity

The breast-fed infant intestine is often colonized by particular bifidobacteria, and human milk oligosaccharides (HMOs) are considered to be bifidogenic. Recent studies showed that Bifidobacterium longum subsp. infantis can grow on HMOs as the sole carbon source. This ability has been ascribed to th...