Retinal Function and Neural Conduction Along the Visual Pathways in Affected and Unaffected Carriers With Leber's Hereditary Optic Neuropathy

• Published in: Investigative ophthalmology & visual science Vol. 54; no. 10; p. 6893
• Main Authors: Ziccardi, Lucia, Sadun, Federico, De Negri, Anna Maria, Barboni, Piero, Savini, Giacomo, Borrelli, Enrico, Morgia, Chiara La, Carelli, Valerio, Parisi, Vincenzo
• Format: Journal Article
• Language: English
• Published: United States 21.10.2013
• Subjects: Adult; Analysis of Variance; Case-Control Studies; Electroretinography; Evoked Potentials, Visual - physiology; Female; Humans; Male; Middle Aged; Optic Atrophy, Hereditary, Leber - genetics; Optic Atrophy, Hereditary, Leber - physiopathology; Retinal Ganglion Cells - physiology; Visual Acuity - physiology; Visual Fields - physiology; Visual Pathways - physiology; Young Adult; pattern electroretinogram; pattern visual evoked potentials; Leber's hereditary optic neuropathy; mitochondrial optic neuropathy; retinal ganglion cells function

We assessed retinal ganglion cell (RGC) function, and established a correlation between the neural conduction along the visual pathways and the retinal involvement in Leber's hereditary optic neuropathy (LHON). A total of 39 individuals carrying a LHON mutation (mean age, 33.35 ± 8.4 years), LH...