High Frequency of Cardiovascular Complications in Tunisian Kawasaki Disease Patients: Need for a Further Awareness

The outcome of Kawasaki disease (KD) depends on cardiovascular complications (CVCs). This study aimed to explore diagnostic features and CVCs in Tunisian patients with KD. In total, 33 Tunisian patients (age, 2.9 ± 2.2 years) fulfilling the diagnosis criteria of KD, were retrospectively reviewed. No...

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Published inJournal of tropical pediatrics (1980) Vol. 65; no. 3; p. 217
Main Authors Ben Chehida, Amel, Ben Messaoud, Sana, Ben Abdelaziz, Rim, Boudabous, Hela, Oujra, Mariem, Ben Turkia, Hadhami, Abdelmoula, Mohamed Slim, Azzouz, Hatem, Hakim, Kaothar, Tebib, Neji
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LanguageEnglish
Published England 01.06.2019
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Abstract The outcome of Kawasaki disease (KD) depends on cardiovascular complications (CVCs). This study aimed to explore diagnostic features and CVCs in Tunisian patients with KD. In total, 33 Tunisian patients (age, 2.9 ± 2.2 years) fulfilling the diagnosis criteria of KD, were retrospectively reviewed. Nonparametric tests were used to compare the two groups with regards to coronary complications (CCs). Diagnosis of KD was established at day 11 ± 5.1 from the beginning of the fever. Apyrexia was obtained in an average of 29 h after completion of intravenous immunoglobulin. CVCs were identified in 52% of cases: CC in 15 patients (giant aneurysm >8 mm in five patients) and non-CCs in 6 patients (severe in three patients). CCs were more frequently associated with the male sex (p = 0.037), fever lasting >8 days (p = 0.028) and longer time to apyrexia (p = 0.031). In Tunisia, better knowledge and monitoring of KD are warranted.
AbstractList The outcome of Kawasaki disease (KD) depends on cardiovascular complications (CVCs). This study aimed to explore diagnostic features and CVCs in Tunisian patients with KD. In total, 33 Tunisian patients (age, 2.9 ± 2.2 years) fulfilling the diagnosis criteria of KD, were retrospectively reviewed. Nonparametric tests were used to compare the two groups with regards to coronary complications (CCs). Diagnosis of KD was established at day 11 ± 5.1 from the beginning of the fever. Apyrexia was obtained in an average of 29 h after completion of intravenous immunoglobulin. CVCs were identified in 52% of cases: CC in 15 patients (giant aneurysm >8 mm in five patients) and non-CCs in 6 patients (severe in three patients). CCs were more frequently associated with the male sex (p = 0.037), fever lasting >8 days (p = 0.028) and longer time to apyrexia (p = 0.031). In Tunisia, better knowledge and monitoring of KD are warranted.
Author Boudabous, Hela
Abdelmoula, Mohamed Slim
Ben Abdelaziz, Rim
Azzouz, Hatem
Tebib, Neji
Ben Chehida, Amel
Ben Turkia, Hadhami
Hakim, Kaothar
Oujra, Mariem
Ben Messaoud, Sana
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  surname: Ben Chehida
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  givenname: Sana
  surname: Ben Messaoud
  fullname: Ben Messaoud, Sana
  organization: Pediatric Department, La Rabta Hospital, Faculty of Medecine of Tunis, University of Tunis El Manar, Jabberi, Jebal Lakhdhar, Tunis, Tunisia
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  givenname: Rim
  surname: Ben Abdelaziz
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  organization: Pediatric Department, La Rabta Hospital, Faculty of Medecine of Tunis, University of Tunis El Manar, Jabberi, Jebal Lakhdhar, Tunis, Tunisia
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  givenname: Hela
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  givenname: Mohamed Slim
  surname: Abdelmoula
  fullname: Abdelmoula, Mohamed Slim
  organization: Pediatric Department, La Rabta Hospital, Faculty of Medecine of Tunis, University of Tunis El Manar, Jabberi, Jebal Lakhdhar, Tunis, Tunisia
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  givenname: Hatem
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  givenname: Kaothar
  surname: Hakim
  fullname: Hakim, Kaothar
  organization: Pediatric Cardiology Department, La Rabta Hospital, Faculty of Medecine of Tunis, University of Tunis El Manar, Jabberi, Jebal Lakhdhar, Tunis, Tunisia
– sequence: 10
  givenname: Neji
  surname: Tebib
  fullname: Tebib, Neji
  organization: Pediatric Department, La Rabta Hospital, Faculty of Medecine of Tunis, University of Tunis El Manar, Jabberi, Jebal Lakhdhar, Tunis, Tunisia
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crossref_primary_10_4236_ojped_2022_122032
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Keywords computed tomography
aortic aneurysm
mucocutaneous lymph node syndrome
coronary aneurysm
echocardiography
myocardial infarction
Language English
License The Author(s) [2018]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
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PublicationTitle Journal of tropical pediatrics (1980)
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StartPage 217
SubjectTerms Child, Preschool
Comorbidity
Coronary Aneurysm - diagnostic imaging
Coronary Aneurysm - epidemiology
Coronary Aneurysm - etiology
Coronary Vessel Anomalies - diagnostic imaging
Coronary Vessel Anomalies - epidemiology
Delayed Diagnosis
Echocardiography
Female
Fever of Unknown Origin - epidemiology
Humans
Immunoglobulins, Intravenous - administration & dosage
Incidence
Infant
Male
Mucocutaneous Lymph Node Syndrome - diagnostic imaging
Mucocutaneous Lymph Node Syndrome - drug therapy
Mucocutaneous Lymph Node Syndrome - epidemiology
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - epidemiology
Retrospective Studies
Sex Factors
Tomography, X-Ray Computed
Treatment Outcome
Tunisia - epidemiology
Title High Frequency of Cardiovascular Complications in Tunisian Kawasaki Disease Patients: Need for a Further Awareness
URI https://www.ncbi.nlm.nih.gov/pubmed/29982732
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