First-in-human Evaluation of Safety and Dosimetry of [64Cu]FBP8: A fibrin-binding PET Probe

• Published in: Molecular imaging and biology Vol. 27; no. 1; pp. 99 - 108
• Main Authors: Izquierdo-Garcia, David, Désogère, Pauline, Philip, Anne L., Sosnovik, David E., Catana, Ciprian, Caravan, Peter
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2025; Springer Nature B.V
• Subjects: Adult; Binding; Biodistribution; Blood; Copper Radioisotopes - chemistry; Copper Radioisotopes - pharmacokinetics; Dosimeters; Dosimetry; Estimates; Excretion; Female; Females; Fibrin; Fibrin - metabolism; Fibrosis; Fluorine isotopes; Humans; Imaging; Injection; Lung diseases; Magnetic Resonance Imaging; Male; Males; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Prospective Studies; Radiology; Radiometry; Renal function; Research Article; Thrombosis; Tissue Distribution; Urinary bladder; Young Adult; Fibrin; Positron emission tomography (PET); PET/MRI; Magnetic resonance imaging (MRI); Dosimetry; Effective dose; Probe; Biodistribution; Blood clots

Purpose This study presents for the first time in humans the biodistribution, clearance and dosimetry estimates of [ 64 Cu]Fibrin Binding Probe #8 ([ 64 Cu]FBP8) in healthy subjects. [ 64 Cu]FBP8-PET previously demonstrated its potential in two recent applications: thrombus imaging and pulmonary fib...