Linkage Disequilibrium Between TNF-α-308 G/A Promoter and Histocompatibility Leukocyte Antigen Alleles in Han-Nationality Lung Transplant Recipients From Eastern China

• Published in: Experimental and clinical transplantation Vol. 11; no. 3; pp. 264 - 269
• Main Authors: Huijun, Mu, Ji, Zhang, Ping, Xie, Jingyu, Chen, Bin, Zhang
• Format: Journal Article
• Language: English
• Published: Turkey 01.06.2013
• Subjects: Acute Disease; Adolescent; Adult; Aged; Asian Continental Ancestry Group - genetics; Chi-Square Distribution; China - epidemiology; Female; Gene Frequency; Genetic Predisposition to Disease; Graft Rejection - ethnology; Graft Rejection - genetics; Graft Rejection - immunology; HLA Antigens - genetics; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-DRB1 Chains - genetics; Humans; Linkage Disequilibrium; Lung Transplantation - adverse effects; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Risk Factors; Time Factors; Tumor Necrosis Factor-alpha - genetics; Young Adult; China

Genes encoding histocompatibility leukocyte antigen (HLA) and proinflammatory cytokines are involved in rejection after organ transplant. The authors explored the association between HLA alleles and the tumor necrosis factor (TNF)- α-308 G/A promoter region in lung transplant recipients of Han natio...