Wharton's Jelly Mesenchymal Stem Cells: Shaping the Future of Osteoarthritis Therapy with Advancements in Chitosan-Hyaluronic Acid Scaffolds

• Published in: Stem cells and development Vol. 34; no. 1-2; p. 1
• Main Authors: Ghamrawi, Ahed, Basso, Rasha, Shakik, Nour, Haddad, Lara, Nasr, Zeina, Harmouch, Chaza
• Format: Journal Article
• Language: English
• Published: United States 01.01.2025
• Subjects: Animals; Cell Differentiation; Chitosan - chemistry; Chitosan - pharmacology; Chondrocytes - cytology; Chondrocytes - metabolism; Chondrogenesis - drug effects; Humans; Hyaluronic Acid - chemistry; Hyaluronic Acid - pharmacology; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Osteoarthritis - pathology; Osteoarthritis - therapy; Tissue Engineering - methods; Tissue Scaffolds - chemistry; Wharton Jelly - cytology; stem cells; chondrogenesis; MSC; regeneration; cell therapy

This review explores the potential of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) in cartilage regeneration and osteoarthritis treatment. It covers key factors influencing chondrogenesis, including growth factors, cytokines, and hypoxia, focusing on precise timing. The effectivenes...