Systematic analysis of the gerontome reveals links between aging and age-related diseases

• Published in: Human molecular genetics Vol. 25; no. 21; pp. ddw307 - 4818
• Main Authors: Fernandes, Maria, Wan, Cen, Tacutu, Robi, Barardo, Diogo, Rajput, Ashish, Wang, Jingwei, Thoppil, Harikrishnan, Thornton, Daniel, Yang, Chenhao, Freitas, Alex, de Magalhães, João Pedro
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2016
• Subjects: Age Factors; Aging - genetics; Animals; Caenorhabditis elegans; Databases, Nucleic Acid; Drosophila; Evolution, Molecular; Genome, Human; Humans; Longevity - genetics; Mice; Saccharomyces cerevisiae; Sequence Analysis, DNA - methods

In model organisms, over 2,000 genes have been shown to modulate aging, the collection of which we call the ‘gerontome’. Although some individual aging-related genes have been the subject of intense scrutiny, their analysis as a whole has been limited. In particular, the genetic interaction of aging...