Probability of radiation-induced complications for normal tissues with parallel architecture subject to non-uniform irradiation

• Published in: Medical physics (Lancaster) Vol. 20; no. 3; p. 613
• Main Authors: Jackson, A, Kutcher, G J, Yorke, E D
• Format: Journal Article
• Language: English
• Published: United States 01.05.1993
• Subjects: Dose-Response Relationship, Radiation; Humans; Kidney - radiation effects; Liver - radiation effects; Mathematics; Models, Biological; Neoplasms - radiotherapy; Probability; Radiation Injuries - epidemiology

A biologically based model is developed to predict radiation-induced normal tissue complication probability (NTCP) in inhomogeneously irradiated organs such as the lung or the kidney. The organ is assumed to be composed of independent functional subunits (FSUs) organized with a parallel architecture...