Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum

• Published in: Alzheimer's & dementia Vol. 21; no. 7; pp. e70395 - n/a
• Main Authors: Labuza, Amanda, Alldred, Melissa J., Pidikiti, Harshitha, Malek‐Ahmadi, Michael H., Lee, Sang Han, Heguy, Adriana, Coleman, Paul D., Chakrabarty, Souparna, Chiosis, Gabriela, Mufson, Elliott J., Ginsberg, Stephen D.
• Format: Journal Article
• Language: English
• Published: United States John Wiley and Sons Inc 01.07.2025
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease spectrum; bioinformatics; Cognitive Dysfunction - genetics; Cognitive Dysfunction - pathology; Disease Progression; Female; frontal cortex; Frontal Lobe - metabolism; Frontal Lobe - pathology; gene expression; Humans; Male; mild cognitive impairment; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Prodromal Symptoms; Pyramidal Cells - metabolism; Pyramidal Cells - pathology; pyramidal neurons; RNA sequencing; selective vulnerability; RNA sequencing; frontal cortex; bioinformatics; Alzheimer's disease spectrum; pyramidal neurons; mild cognitive impairment; selective vulnerability; gene expression

INTRODUCTION Underlying causes of Alzheimer's disease (AD) remain unknown, making it imperative to identify molecular mechanisms driving the pathobiology of AD onset and progression. METHODS Laser capture microdissection was used to isolate layer III pyramidal neurons from post mortem human pre...