Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum - Labuza, Amanda; Alldred, Melissa J.; Pidikiti, Harshitha; Malek‐Ahmadi, Michael H.; Lee, Sang Han; Heguy, Adriana; Coleman, Paul D.; Chakrabarty, Souparna; Chiosis, Gabriela; Mufson, Elliott J.; Ginsberg, Stephen D. (Alzheimer's & dementia, 2025)
Keywords: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease spectrum; bioinformatics; Cognitive Dysfunction - genetics; Cognitive Dysfunction - pathology; Disease Progression; Female; frontal cortex; Frontal Lobe - metabolism; Frontal Lobe - pathology; gene expression; Humans; Male; mild cognitive impairment; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Prodromal Symptoms; Pyramidal Cells - metabolism; Pyramidal Cells - pathology; pyramidal neurons; RNA sequencing; selective vulnerability; RNA sequencing; frontal cortex; bioinformatics; Alzheimer's disease spectrum; pyramidal neurons; mild cognitive impairment; selective vulnerability; gene expression