Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice

• Published in: Clinical and experimental immunology Vol. 173; no. 1; pp. 67 - 75
• Main Authors: Kurien, B. T., Dsouza, A., Igoe, A., Lee, Y. J., Maier‐Moore, J. S., Gordon, T., Jackson, M., Scofield, R. H.
• Format: Journal Article
• Language: English
• Published: England Blackwell Science Inc 01.07.2013
• Subjects: Amino Acid Sequence; animal models/studies – mice/rats; Animals; Antibodies, Antinuclear - biosynthesis; Antibodies, Antinuclear - immunology; anti‐SSA(Ro)/SSB(La) antibodies; Autoantigens - immunology; autoimmunity; Autoimmunity - genetics; Autoimmunity - immunology; Carbachol - pharmacology; Disease Models, Animal; Epitopes - immunology; Freund's Adjuvant; genetics; H-2 Antigens - genetics; H-2 Antigens - immunology; Haplotypes; Immunization; Lymphocyte Subsets - immunology; Lymphocyte Subsets - pathology; Male; Mice; Mice, Inbred Strains - genetics; Mice, Inbred Strains - immunology; Molecular Sequence Data; Muscle, Smooth - drug effects; Muscle, Smooth - immunology; Peptide Fragments - immunology; Prodromal Symptoms; Receptor, Muscarinic M3 - drug effects; Receptor, Muscarinic M3 - immunology; Ribonucleoproteins - immunology; RNA, Small Cytoplasmic - immunology; Salivary Glands - pathology; Salivation; Sjogren's syndrome; Sjogren's Syndrome - etiology; Sjogren's Syndrome - immunology; Specific Pathogen-Free Organisms; SS-B Antigen; Translational Studies; Urinary Bladder; Xerostomia - etiology; Xerostomia - immunology

Summary Sjögren's syndrome is a chronic illness manifested characteristically by immune injury to the salivary and lacrimal glands, resulting in dry mouth/eyes. Anti‐Ro [Sjögren's syndrome antigen A (SSA)] and anti‐La [Sjögren's syndrome antigen B (SSB)] autoantibodies are found frequ...