Thermosensitive acetylated carboxymethyl chitosan gel depot systems sustained release caffeic acid phenethyl ester for periodontitis treatment

• Published in: Polymers for advanced technologies Vol. 34; no. 1; pp. 155 - 165
• Main Authors: Peng, Chengjun, Wang, Guichun, Wang, Yuxiao, Tang, Maomao, Ma, Xiaodong, Chang, Xiangwei, Guo, Jian, Gui, Shuangying
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2023; Wiley Subscription Services, Inc
• Subjects: acetylated carboxymethyl chitosan; Alkaline phosphatase; Biocompatibility; caffeic acid phenethyl ester; Chitosan; Cytokines; Drug delivery systems; Hydrogels; Macrophages; Oxidation; periodontitis; Soft tissues; Stem cells; Sustained release; thermosensitive hydrogel

Periodontitis is a chronic inflammatory disease of tooth support tissues leading to progressive destruction of periodontal soft tissues as well as alveolar bone, and can be treated with anti‐inflammatory and bone‐protective agents to prevent disease progression. Caffeic acid phenethyl ester (CAPE) i...