Serum and Follicular Fluid Leptin during in Vitro Fertilization: Relationship among Leptin Increase, Body Fat Mass, and Reduced Ovarian Response

• Published in: The journal of clinical endocrinology and metabolism Vol. 84; no. 9; pp. 3135 - 3139
• Main Authors: Bützow, Tarja L, Moilanen, Jarna M, Lehtovirta, Mikko, Tuomi, Tiinamaija, Hovatta, Outi, Siegberg, Rita, Nilsson, Carl-Gustaf, Apter, Dan
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Copyright Oxford University Press 01.09.1999; Endocrine Society
• Subjects: Adipose Tissue; Adult; Biological and medical sciences; Birth control; Body Composition; Body Constitution; Body Mass Index; Estradiol - blood; Fasting; Female; Fertilization in Vitro; Follicle Stimulating Hormone - administration & dosage; Follicle Stimulating Hormone - blood; Follicular Fluid - metabolism; Gynecology. Andrology. Obstetrics; Humans; Leptin; Linear Models; Medical sciences; Ovary - physiology; Ovulation Induction; Proteins - analysis; Proteins - metabolism; Sterility. Assisted procreation; Europe; Finland; Human; Treatment efficiency; Fat mass; Body composition; Blood plasma; In vitro fertilization embryo transfer; Chemotherapy; Nafarelin; Treatment; Leptin; Adult; Evolution; Female; Ovarian follicle; Comparative study

ABSTRACTThe satiety factor leptin is expressed in several reproductive tissues, but its role in the control of reproductive physiology is not well understood. We studied leptin concentrations in the sera and follicle fluids of 52 women [body fat mass percentage (BFM%) range, 19.6-38.8%] undergoing p...