Multi-Objective Optimization of Experiments Using Curvature and Fisher Information Matrix

• Published in: Processes Vol. 5; no. 4; p. 63
• Main Authors: Manesso, Erica, Sridharan, Srinath, Gunawan, Rudiyanto
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.12.2017
• Subjects: Batch culture; Biological activity; Curvature; Data processing; Design of experiments; Design parameters; Dynamic models; Fermentation; Fisher information; Multiple objective analysis; Nonlinear systems; Nonlinearity; Optimization; Parameter estimation; Parameter identification; Yeast

The bottleneck in creating dynamic models of biological networks and processes often lies in estimating unknown kinetic model parameters from experimental data. In this regard, experimental conditions have a strong influence on parameter identifiability and should therefore be optimized to give the...