Effects of carvedilol and metoprolol on the myocardium during mechanical unloading in a rat heterotopic heart transplantation model

• Published in: Cardiology in the young Vol. 31; no. 8; pp. 1269 - 1274
• Main Authors: Kim, Geena, Kil, Hong Ryang, Quan, Cheng, Lee, Sang Su
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2021
• Subjects: Adrenergic receptors; Apoptosis; Bridge failure; Ca2+-transporting ATPase; Caspase-3; Congestive heart failure; Coronary vessels; Diameters; DNA nucleotidylexotransferase; Drug dosages; Fibrosis; Gene expression; Heart failure; Heart transplantation; Heart transplants; Labeling; Mechanical unloading; Metoprolol; Myocardium; Myocytes; Original Article; Other; Polymerase chain reaction; Pulmonary arteries; Recovery; Transplantation; Transplants; Transplants & implants; Veins & arteries; Ventricle; Ventricular assist devices; United States > US; myocardium; metoprolol; Carvedilol; heterotopic; transplantation

Left ventricular assist devices enable recovery from severe heart failure and serve as a bridge to heart transplantation. However, chronic mechanical unloading can impair myocardial recovery. We aimed to assess myocyte size, fibrosis, apoptosis, and β-adrenoreceptor levels after rats with left ventr...