In situ grown magnetic COF@MOF with a phosphoserine anchor for in-depth N -glycopeptide analysis in serum

• Published in: Analyst (London) Vol. 148; no. 23; pp. 5864 - 5872
• Main Authors: Guo, Yimin, Hua, Shuwen, Wang, Baichun, Wang, Bing, Ding, Chuan-Fan, Yan, Yinghua
• Format: Journal Article
• Language: English
• Published: London Royal Society of Chemistry 20.11.2023
• Subjects: Biological activity; Biological properties; Cancer; Cell adhesion; Cervical cancer; Gene expression; Glycopeptides; Glycoproteins; Iron oxides; Metal-organic frameworks

A hydrophilic phosphoserine-functionalized magnetic organic framework composite (termed Fe 3 O 4 @COF@MOF-PS) was synthesized by an in situ growth strategy for effective capture of N -glycopeptides. Fe 3 O 4 @COF@MOF-PS exhibited high sensitivity (0.2 fmol μL −1 ), outstanding exclusion of size capa...