Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

• Published in: Advanced science p. e04851
• Main Authors: Chen, Fan, Tian, Xue‐Fei, Yang, Teng, Dai, Yu‐Jie, Chen, Da‐Yuan, Chen, Hong‐Bo, Shimura, Takaya, Li, Xin‐Fang, Sha, Chu‐Lin, Ji, Qing, Cao, Jun, Fang, Mei‐Yu, Shang, Jin‐Biao, Fang, Jian‐Min, Lu, Ye, Zheng, Wei‐Hui, Guo, Peng, Tan, Wei‐Hong
• Format: Journal Article
• Language: English
• Published: Germany 20.06.2025
• Subjects: pyroptosis; anti‐tumor immunity; antibody‐drug conjugate

Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor‐specific and controllable inducers. Here, it is reported that tumor‐specific pyroptosis can be spatiote...