Methodological advances in the design of peptide-based vaccines

• Published in: Drug discovery today Vol. 27; no. 5; pp. 1367 - 1380
• Main Authors: Kalita, Parismita, Tripathi, Timir
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2022
• Subjects: Adjuvants; Computational Biology - methods; Epitopes; Epitopes, T-Lymphocyte - genetics; Immune response; Immunogenicity; Immunoinformatics; Peptide vaccine; Peptides; Reverse vaccinology; Subunit; Vaccine design; Vaccines, Subunit; APCs; Immune response; Reverse vaccinology; Adjuvants; MHC; Epitopes; Peptide vaccine; Subunit; CD8/CD4; Immunoinformatics; Vaccine design; Immunogenicity; DCs; HLA; ISCOMs

•Peptide vaccines are economical, safer and more efficient than conventional vaccines.•Genomics, proteomics and immunoinformatics have accelerated peptide vaccine design.•Exploring new adjuvants and delivery systems could create more potent vaccines.•Sophisticated imaging techniques enable real-time...