Dynamic Modelling and Optimisation of the Batch Enzymatic Synthesis of Amoxicillin

• Published in: Processes Vol. 7; no. 6; p. 318
• Main Authors: Cuthbertson, Andrew B., Rodman, Alistair D., Diab, Samir, Gerogiorgis, Dimitrios I.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2019
• Subjects: Amides; Aminopenicillanic acid; Amoxicillin; Antibiotics; Batch processes; Design; Dynamic models; Enzymatic synthesis; Enzymes; Modelling; Operating temperature; Optimal control; Optimization; Parameter estimation; Pharmaceuticals; Product specifications; Raw materials; Simulation; Substrates; Temperature; Urinary tract; β-Lactam antibiotics

Amoxicillin belongs to the β-lactam family of antibiotics, a class of highly consumed pharmaceutical products used for the treatment of respiratory and urinary tract infections, and is listed as a World Health Organisation (WHO) “Essential Medicine”. The demonstrated batch enzymatic synthesis of amo...