Doubtful use of placebo following placebo in recent controlled trials of lasmiditan and ubrogepant for the treatment of migraine attacks

• Published in: Cephalalgia Vol. 42; no. 1; pp. 82 - 85
• Main Authors: Tfelt-Hansen, Peer, Jørgensen, Karsten, Diener, Hans-Christoph
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2022
• Subjects: Benzamides; Controlled Clinical Trials as Topic; Humans; Migraine Disorders - drug therapy; Piperidines; Pyridines - therapeutic use; Pyrroles; ubrogepant; lasmiditan; Placebo

Purpose In four large controlled trials with lasmiditan and ubrogepant placebo was administered in the first step to demonstrate an effect on migraine attack. In the same trials the investigators also asked the question: is a second dose of the drug effective in non-responders to the first dose? In...