Serum levels of microRNAs can specifically predict liver injury of chronic hepatitis B

• Published in: World journal of gastroenterology : WJG Vol. 18; no. 37; pp. 5188 - 5196
• Main Authors: Zhang, Hui, Li, Qing-Ya, Guo, Zhi-Zhong, Guan, Yan, Du, Jia, Lu, Yi-Yu, Hu, Yi-Yang, Liu, Ping, Huang, Shuang, Su, Shi-Bing
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 07.10.2012
• Subjects: Adult; Biomarkers - metabolism; Case-Control Studies; Fatty Liver - blood; Female; Gene Expression Profiling - methods; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - complications; Humans; Inflammation; Liver - injuries; Liver - virology; Male; microRNA; MicroRNAs - metabolism; Middle Aged; miRNA; Oligonucleotide Array Sequence Analysis; Original; ROC Curve; Sensitivity and Specificity; 典型相关分析; 慢性乙型肝炎; 肝损伤; 血清样品; 逆转录聚合酶链反应; 预测; Chronic hepatitis B; Nonalcohlic steatohepatitis; Serum microRNAs; Liver injury
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v18.i37.5188

AIM： To investigate whether circulating microRNAs （miRNAs） can serve as molecular markers to predict liver injury resulted from chronic hepatitis B （CHB）. METHODS： The profiles of serum miRNA expression were first generated with serum samples collected from 10 patients with CHB and 10 healthy donors...