PyRICo‐Pilot: pyridostigmine to reduce the duration of postoperative ileus after colorectal surgery – a phase II study

• Published in: Colorectal disease Vol. 23; no. 8; pp. 2154 - 2160
• Main Authors: Dudi‐Venkata, Nagendra N., Kroon, Hidde M., Bedrikovetski, Sergei, Traeger, Luke, Lewis, Mark, Lawrence, Matthew J., Hunter, Ronald A., Moore, James W., Thomas, Michelle L., Sammour, Tarik
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.08.2021
• Subjects: Acetylcholinesterase; Adverse events; Body mass index; Colorectal surgery; Inflammation; Parasympathetic nervous system; Patients; Pyridostigmine; Surgery; Vomiting

Abstract Aim Postoperative ileus (POI) is a major problem after colorectal surgery. Acetylcholinesterase inhibitors such as pyridostigmine increase gastrointestinal (GI) motility through a cholinergic anti‐inflammatory pathway. The purpose of this phase II pilot study is to determine the safety of o...