Measurement variability of blood–brain barrier permeability using dynamic contrast-enhanced magnetic resonance imaging

• Published in: Imaging neuroscience (Cambridge, Mass.) Vol. 2; pp. 1 - 16
• Main Authors: Varatharaj, Aravinthan, Jacob, Carmen, Darekar, Angela, Yuen, Brian, Cramer, Stig, Larsson, Henrik, Galea, Ian
• Format: Journal Article
• Language: English
• Published: 255 Main Street, 9th Floor, Cambridge, Massachusetts 02142, USA MIT Press 22.10.2024
• Subjects: blood–brain barrier; dynamic contrast-enhanced magnetic resonance imaging; measurement variability; scan–rescan; measurement variability; scan–rescan; dynamic contrast-enhanced magnetic resonance imaging; blood–brain barrier
• ISSN: 2837-6056; 2837-6056
• DOI: 10.1162/imag_a_00324

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to quantify the blood–brain barrier (BBB) permeability–surface area product. Serial measurements can indicate changes in BBB health, of interest to the study of normal physiology, neurological disease, and the effect of therapeut...