A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones inhibits intracellular growth and persistence of Chlamydia trachomatis

• Published in: Journal of medical microbiology Vol. 65; no. 1; pp. 91 - 98
• Main Authors: Zigangirova, Naylia A., Kost, Elena A., Didenko, Lubov V., Kapotina, Lydia N., Zayakin, Egor S., Luyksaar, Sergei I., Morgunova, Elena Y., Fedina, Elena D., Artyukhova, Olga A., Samorodov, Andrey V., Kobets, Natalya V.
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Animals; Bacterial Adhesion - drug effects; Bacterial Proteins; Cell Line; Chlamydia trachomatis - drug effects; Chlamydia trachomatis - growth & development; Dose-Response Relationship, Drug; Mice; Molecular Weight; Penicillins - pharmacology; Thiadiazines - chemistry; Thiadiazines - pharmacology; Type III Secretion Systems - antagonists & inhibitors

Chlamydia trachomatis is one of the most common sexually transmitted pathogens in the world and often causes chronic inflammatory diseases that are insensitive to antibiotics. The type 3 secretion system (T3SS) of pathogenic bacteria is a promising target for therapeutic intervention aimed at bacter...