Synthesis and Antibacterial and Antifungal Activity of 3-(Azol-1-Yl)-6-R-1,2,4,5-Tetrazines

Nucleophilic substitution and 1,3-dipolar cycloaddition reactions were used to synthesize 3,6-disubstituted derivatives of simm-tetrazine containing azolyl, aminoalkyl, and oxyalkyl fragments. The antibacterial activity of the resulting compounds was studied using the obligate pathogen Neisseria gon...

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Published inPharmaceutical chemistry journal Vol. 53; no. 10; pp. 899 - 904
Main Authors Ishmetova, R. I., Gerasimova, N. A., Evstigneeva, N. P., Belyaninova, I. A., Ignatenko, N. K., Mukhina, A. A., Zil’berberg, N. V., Kungurov, N. V., Rusinov, G. L., Chupakhin, O. N., Charushin, V. N.
Format Journal Article
LanguageEnglish
Published New York Springer US 2020
Subjects
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
1,2,4,5-tetrazines
antibacterial and antifungal activity
nucleophilic substitution
1,3-dipolar cycloaddition
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Summary:Nucleophilic substitution and 1,3-dipolar cycloaddition reactions were used to synthesize 3,6-disubstituted derivatives of simm-tetrazine containing azolyl, aminoalkyl, and oxyalkyl fragments. The antibacterial activity of the resulting compounds was studied using the obligate pathogen Neisseria gonorrhoeae and opportunistic pathogenic microorganisms, while antifungal activity was assessed using anthropo- and zooanthropophilic dermatophytes.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02097-y