Relationship between Carotid Atherosclerosis and Plasma Endothelin-1 Concentration in Senile Patients with Hypertension
The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83M, 129F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean a...
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| Published in | Nihon Rōnen Igakkai zasshi Vol. 34; no. 12; pp. 1009 - 1016 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japan
The Japan Geriatrics Society
1997
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0300-9173 |
| DOI | 10.3143/geriatrics.34.1009 |
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| Abstract | The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83M, 129F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean age, 61 years) were enrolled in the study. The maximum thicknesses of the intima-media complex (IMTmax) in the right common carotid artery (CCA) and the right internal carotid artery (ICA) was measured by B-mode ultrasonography, and ET-1 was measured by enzyme immunoassay. ET-1 levels were significantly higher in the hypertensive patients than in the control subjects. In middle-aged patients (35-64 years old), IMTmax values of the ICA in patients with high ET-1 concentrations (ET-≥1.71pg/ml) were significantly higher than in patients with normal ET-1 concentrations (ET-1<1.71pg/ml). However, the IMTmax of the CCA did not show a similar correlation. In senile patients (65-83 years old), both the CCA and ICA IMTmax values were significantly higher in patients with high ET-1 concentrations than in those with normal ET-1 concentrations. These results indicate that high ET-1 levels in middle-aged patients with essential hypertension may play a role in the progression of ICA atherosclerosis. High ET-1 levels in senile patients with essential hypertension may cause progression of atherosclerosis in both the ICA and CCA. |
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| AbstractList | The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83M, 129F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean age, 61 years) were enrolled in the study. The maximum thicknesses of the intima-media complex (IMTmax) in the right common carotid artery (CCA) and the right internal carotid artery (ICA) was measured by B-mode ultrasonography, and ET-1 was measured by enzyme immunoassay. ET-1 levels were significantly higher in the hypertensive patients than in the control subjects. In middle-aged patients (35-64 years old), IMTmax values of the ICA in patients with high ET-1 concentrations (ET-≥1.71pg/ml) were significantly higher than in patients with normal ET-1 concentrations (ET-1<1.71pg/ml). However, the IMTmax of the CCA did not show a similar correlation. In senile patients (65-83 years old), both the CCA and ICA IMTmax values were significantly higher in patients with high ET-1 concentrations than in those with normal ET-1 concentrations. These results indicate that high ET-1 levels in middle-aged patients with essential hypertension may play a role in the progression of ICA atherosclerosis. High ET-1 levels in senile patients with essential hypertension may cause progression of atherosclerosis in both the ICA and CCA. The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83 M, 129 F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean age, 61 years) were enrolled in the study. The maximum thicknesses of the intima-media complex (IMTmax) in the right common carotid artery (CCA) and the right internal carotid artery (ICA) was measured by B-mode ultrasonography, and ET-1 was measured by enzyme immunoassay. ET-1 levels were significantly higher in the hypertensive patients than in the control subjects. In middle-aged patients (35-64 years old), IMTmax values of the ICA in patients with high ET-1 concentrations (ET-1 > or = 1.71 pg/ml) were significantly higher than in patients with normal ET-1 concentrations (ET-1 < 1.71 pg/ml). However, the IMTmax of the CCA did not show a similar correlation. In senile patients (65-83 years old), both the CCA and ICA IMTmax values were significantly higher in patients with high ET-1 concentrations than in those with normal ET-1 concentrations. These results indicate that high ET-1 levels in middle-aged patients with essential hypertension may play a role in the progression of ICA atherosclerosis. High ET-1 levels in senile patients with essential hypertension may cause progression of atherosclerosis in both the ICA and CCA.The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83 M, 129 F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean age, 61 years) were enrolled in the study. The maximum thicknesses of the intima-media complex (IMTmax) in the right common carotid artery (CCA) and the right internal carotid artery (ICA) was measured by B-mode ultrasonography, and ET-1 was measured by enzyme immunoassay. ET-1 levels were significantly higher in the hypertensive patients than in the control subjects. In middle-aged patients (35-64 years old), IMTmax values of the ICA in patients with high ET-1 concentrations (ET-1 > or = 1.71 pg/ml) were significantly higher than in patients with normal ET-1 concentrations (ET-1 < 1.71 pg/ml). However, the IMTmax of the CCA did not show a similar correlation. In senile patients (65-83 years old), both the CCA and ICA IMTmax values were significantly higher in patients with high ET-1 concentrations than in those with normal ET-1 concentrations. These results indicate that high ET-1 levels in middle-aged patients with essential hypertension may play a role in the progression of ICA atherosclerosis. High ET-1 levels in senile patients with essential hypertension may cause progression of atherosclerosis in both the ICA and CCA. The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A total of 212 patients (83 M, 129 F; mean age, 63 years) with essential hypertension (WHO stage I-II), and 109 age-matched control subjects (mean age, 61 years) were enrolled in the study. The maximum thicknesses of the intima-media complex (IMTmax) in the right common carotid artery (CCA) and the right internal carotid artery (ICA) was measured by B-mode ultrasonography, and ET-1 was measured by enzyme immunoassay. ET-1 levels were significantly higher in the hypertensive patients than in the control subjects. In middle-aged patients (35-64 years old), IMTmax values of the ICA in patients with high ET-1 concentrations (ET-1 > or = 1.71 pg/ml) were significantly higher than in patients with normal ET-1 concentrations (ET-1 < 1.71 pg/ml). However, the IMTmax of the CCA did not show a similar correlation. In senile patients (65-83 years old), both the CCA and ICA IMTmax values were significantly higher in patients with high ET-1 concentrations than in those with normal ET-1 concentrations. These results indicate that high ET-1 levels in middle-aged patients with essential hypertension may play a role in the progression of ICA atherosclerosis. High ET-1 levels in senile patients with essential hypertension may cause progression of atherosclerosis in both the ICA and CCA. |
| Author | Yamano, Shigeru Sawai, Nobuyuki Fukui, Rie Minami, Shigetoshi Takaoka, Minoru Nakatani, Akira Dohi, Kazuhiro Yamamoto, Yuta Nomura, Kumiko |
| Author_xml | – sequence: 1 fullname: Yamamoto, Yuta organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Yamano, Shigeru organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Minami, Shigetoshi organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Nomura, Kumiko organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Nakatani, Akira organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Sawai, Nobuyuki organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Fukui, Rie organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Takaoka, Minoru organization: First Department of Internal Medicine, Nara Medical University – sequence: 1 fullname: Dohi, Kazuhiro organization: First Department of Internal Medicine, Nara Medical University |
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Circulation 1986; 74: 1399-1406. 32) 小松本悟, 奈良昌治: 血漿 Endothelin-1 値における加齢の影響について. 日老医誌1995; 32: 664-669. 1) Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415. 25) Friedman MH, Hutchins GM, Bargeron CB, Deters OJ, Mark FF: Correlation between intimal thickness and fluid shear in human arteries. Atherosclerosis 1981; 39: 425-436. 26) 植田初江, 由谷親夫, 今村正美: 頸動脈硬化症の初期病変に関する病理学的検討. 動脈硬化1988; 16: 565-571. 23) Solberg LA, Eggen DA: Locarization and sequence of development of atherosclerotic lesions in the carotid and vertebral arteries. Circulation 1971; 43: 711-724. 19) Bonithon-Kopp C, Scarabin P-Y, Taquet A, Touboul P-J, Malmejac A, Guize L: Risk factors for early carotid atherosclerosis in middle-aged French women. Arterosclerosis and Thrombosis 1991; 11: 966-972. 3) Garg UC, Hassaid A: Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83: 1774-1777. 6) Hirata Y, Takagi Y, Fukuda Y, Marumo F: Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis 1989; 78: 225-228. 8) Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, et al: Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 1990; 172: 1741-1748. 33) Saito Y, Nakao K, Mukoyama M, Shirakami G, Itoh H, Yamada T, et al: Application of monoclonal antibodies for endothelin to hypertensive reserch. Hypertension 1990; 15: 734-738. 10) Handa N, Matsumoto M, Maeda H, Hougaku H, Ogawa S, Fukunaga R, et al: Ultrasonic evaluation of early carotid atherosclerosis. Stroke 1990; 21: 1567-1572. 13) Bogousslavsky J, Regli F: Borderzone infarctions distal to internal carotid artery occulusion: Prognostic implications. Ann Neurol 1986; 20: 346-350. 18) Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R: Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. Atherosclerosis 1988; 70: 253-261. 29) Haudenschild CC, Prescott MF, Chobanian AV: Effects of hypertension and its reversal on aortic intima lesions of the rat. Hypertension 1980; 2: 33-44. 22) 松原純一, 山田育男, 太田敬, 塩野谷恵彦, 佐々木隆一郎, 青木国雄, 新城健蔵: 日本人における頭蓋外の頸動脈病変頻度. 脈管学 1985; 25: 295-298. 15) Salonen JT, Salonen R: Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arteriosclerosis and Thrombosis 1991; 11: 1245-1249. 21) Suzuki N, Matsumoto H, Kitada C, Masaki T, Fujino M: A sensitive sandwich-enzyme immunoassay for human endothelin. J Immunol Method 1989; 118: 245-250. 5) Hamberg M, Svensson J, Samuelsson B: Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Nat Acad Sci USA 1975; 72: 2994-2998. 9) Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, Burnett JG: Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 1991; 325: 997-1001. 7) Bobik A, Grooms A, Millar JA, Mitchell A, Grinpukel S: Growth factor activity of endothelin on vascular smooth muscle. Am J Physiol 1990; 258: C408-C415. 16) Salonen R, Salonen JT: Progression of carotid atherosclerosis and its determinants: A population-based ultrasonography study. Atherosclerosis 1990; 81: 33-40. 34) Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C, et al: A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: Comparison of levels in patients with essential hypertension and normotensive control subjects. Clin Sci 1990; 78: 261-264. 35) Yokokawa K, Tahara H, Kohno M, Murakawa K, Yasunari K, Nakagawa K, et al: Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Ann Intern Med 1991; 114: 213-215. 38) Schiffrin EL, Thibault G: Plasma endothelin in human essential hypertension. Am J Hypertens 1991; 4: 303-308. 28) Owens GK, Schwartz SM: Vascular smooth muscle cell hypertrophy and hyperploidy in the Goldblatt hypertensive rat. Circ Res 1983; 53: 491-501. 39) Douglas SA, Louden C, Vickery-Clark LM, Storer BL, Hart T, Feuerstein GZ, et al: A role for endogenous endothelin-1 in neointimal formation after rat carotid artery baloon angioplasty. Circ Res 1994; 75: 190-197. 31) Shichiri M, Hirata Y, Ando K, Emori T, Ohta K, Kimoto S, et al: Plasma endothelin levels in hypertension and chronic renal failure. Hypertension 1990; 15: 493-496. 36) Nishikibe M, Tsuchida S, Okabe M, Fukuroda T, Shimamoto K, Yano M, et al: Antihypertensive effect of newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model. Life Sci 1993; 52: 717-724. 17) Crouse JR, Harpold GH, Kahl FR, Toole JF, Mckinney WM: Evaluation of a scoring system for extracranial carotid atherosclerosis extent with B-mode ultrasound. Stroke 1986; 17: 270-275. 37) Kohno M, Yasunari K, Murakawa K, Yokokawa K, Horio T, Fukui T, et al: Plasma immunoreactive endothelin in essential hypertension. Am J Med 1990; 88: 614-618. 2) Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-526. 12) 井門浩美, 長束一行, 佐藤洋, 浅岡伸光, 佐野道孝, 増田喜一ほか: 頸動脈病変と危険因子および脳梗塞との関連性. 脈管学1995; 35: 411-417. 27) 丸山路之: 超音波断層法による総頸動脈近位部中内膜肥厚度計測の意義. 脈管学1995; 35: 77-82. 11) Heyman A, Wilkinson WE, Heyden S, Helms MJ, Bartel AG, Karp HR, et al: Risk of stroke in asymptomatic persons with cervical arterial bruits: A population study in Evans county, Georgia. N Engl J Med 1980; 302: 838-841. 4) Folkow B, Johansson B, Mellander S: The comparative effects of angiotensin and noradrenaline on consecutive vascular sections. Acta Physiol Scand 1961; 53: 99-104. 41) Malek AM, Greene AL, Lzumo S: Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc Natl Acad Sci USA 1993; 90: 5999-6003. 24) Sakata N, Joshita T, Ooneda G: Topographical study on arterosclerotic lesions at the bifurcations of human cerebral arteries. Heart and Vessels 1985; 1: 70-73. |
| References_xml | – reference: 12) 井門浩美, 長束一行, 佐藤洋, 浅岡伸光, 佐野道孝, 増田喜一ほか: 頸動脈病変と危険因子および脳梗塞との関連性. 脈管学1995; 35: 411-417. – reference: 27) 丸山路之: 超音波断層法による総頸動脈近位部中内膜肥厚度計測の意義. 脈管学1995; 35: 77-82. – reference: 22) 松原純一, 山田育男, 太田敬, 塩野谷恵彦, 佐々木隆一郎, 青木国雄, 新城健蔵: 日本人における頭蓋外の頸動脈病変頻度. 脈管学 1985; 25: 295-298. – reference: 23) Solberg LA, Eggen DA: Locarization and sequence of development of atherosclerotic lesions in the carotid and vertebral arteries. Circulation 1971; 43: 711-724. – reference: 37) Kohno M, Yasunari K, Murakawa K, Yokokawa K, Horio T, Fukui T, et al: Plasma immunoreactive endothelin in essential hypertension. Am J Med 1990; 88: 614-618. – reference: 6) Hirata Y, Takagi Y, Fukuda Y, Marumo F: Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis 1989; 78: 225-228. – reference: 35) Yokokawa K, Tahara H, Kohno M, Murakawa K, Yasunari K, Nakagawa K, et al: Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Ann Intern Med 1991; 114: 213-215. – reference: 5) Hamberg M, Svensson J, Samuelsson B: Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Nat Acad Sci USA 1975; 72: 2994-2998. – reference: 38) Schiffrin EL, Thibault G: Plasma endothelin in human essential hypertension. Am J Hypertens 1991; 4: 303-308. – reference: 11) Heyman A, Wilkinson WE, Heyden S, Helms MJ, Bartel AG, Karp HR, et al: Risk of stroke in asymptomatic persons with cervical arterial bruits: A population study in Evans county, Georgia. N Engl J Med 1980; 302: 838-841. – reference: 30) Gariepy J, Massonneau M, Levenson J, Heudes D, Simon A: Evidence for in vivo carotid and femoral wall thickening in human hypertension. Hypertension 1993; 22: 111-118. – reference: 14) Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R: Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation 1986; 74: 1399-1406. – reference: 26) 植田初江, 由谷親夫, 今村正美: 頸動脈硬化症の初期病変に関する病理学的検討. 動脈硬化1988; 16: 565-571. – reference: 25) Friedman MH, Hutchins GM, Bargeron CB, Deters OJ, Mark FF: Correlation between intimal thickness and fluid shear in human arteries. Atherosclerosis 1981; 39: 425-436. – reference: 15) Salonen JT, Salonen R: Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arteriosclerosis and Thrombosis 1991; 11: 1245-1249. – reference: 10) Handa N, Matsumoto M, Maeda H, Hougaku H, Ogawa S, Fukunaga R, et al: Ultrasonic evaluation of early carotid atherosclerosis. Stroke 1990; 21: 1567-1572. – reference: 41) Malek AM, Greene AL, Lzumo S: Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc Natl Acad Sci USA 1993; 90: 5999-6003. – reference: 1) Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411-415. – reference: 18) Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R: Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolemic patients. Atherosclerosis 1988; 70: 253-261. – reference: 7) Bobik A, Grooms A, Millar JA, Mitchell A, Grinpukel S: Growth factor activity of endothelin on vascular smooth muscle. Am J Physiol 1990; 258: C408-C415. – reference: 17) Crouse JR, Harpold GH, Kahl FR, Toole JF, Mckinney WM: Evaluation of a scoring system for extracranial carotid atherosclerosis extent with B-mode ultrasound. Stroke 1986; 17: 270-275. – reference: 3) Garg UC, Hassaid A: Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83: 1774-1777. – reference: 16) Salonen R, Salonen JT: Progression of carotid atherosclerosis and its determinants: A population-based ultrasonography study. Atherosclerosis 1990; 81: 33-40. – reference: 13) Bogousslavsky J, Regli F: Borderzone infarctions distal to internal carotid artery occulusion: Prognostic implications. Ann Neurol 1986; 20: 346-350. – reference: 34) Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C, et al: A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: Comparison of levels in patients with essential hypertension and normotensive control subjects. Clin Sci 1990; 78: 261-264. – reference: 24) Sakata N, Joshita T, Ooneda G: Topographical study on arterosclerotic lesions at the bifurcations of human cerebral arteries. Heart and Vessels 1985; 1: 70-73. – reference: 31) Shichiri M, Hirata Y, Ando K, Emori T, Ohta K, Kimoto S, et al: Plasma endothelin levels in hypertension and chronic renal failure. Hypertension 1990; 15: 493-496. – reference: 39) Douglas SA, Louden C, Vickery-Clark LM, Storer BL, Hart T, Feuerstein GZ, et al: A role for endogenous endothelin-1 in neointimal formation after rat carotid artery baloon angioplasty. Circ Res 1994; 75: 190-197. – reference: 20) WHO/ISH Guidelines Sub-Committee: 1993 guidelines for the management of mild hypertension: Memorandum from a World Health Organization/International Society of Hypertension meeting. J Hypertens 1993; 11: 905-918. – reference: 8) Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, et al: Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 1990; 172: 1741-1748. – reference: 29) Haudenschild CC, Prescott MF, Chobanian AV: Effects of hypertension and its reversal on aortic intima lesions of the rat. Hypertension 1980; 2: 33-44. – reference: 36) Nishikibe M, Tsuchida S, Okabe M, Fukuroda T, Shimamoto K, Yano M, et al: Antihypertensive effect of newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model. Life Sci 1993; 52: 717-724. – reference: 21) Suzuki N, Matsumoto H, Kitada C, Masaki T, Fujino M: A sensitive sandwich-enzyme immunoassay for human endothelin. J Immunol Method 1989; 118: 245-250. – reference: 4) Folkow B, Johansson B, Mellander S: The comparative effects of angiotensin and noradrenaline on consecutive vascular sections. 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| Snippet | The relationship between carotid atherosclerosis and plasma endothelin-1 (ET-1) concentration was studied in senile patients with essential hypertension. A... |
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| SubjectTerms | Adult Aged Aged, 80 and over Arteriosclerosis - blood Arteriosclerosis - pathology Carotid Artery Diseases - blood Carotid Artery Diseases - pathology Carotid atherosclerosis Elderly Endothelin-1 Endothelin-1 - blood Essential hypertension Female Humans Hypertension - blood Hypertension - pathology Male Middle Aged Ultrasonography |
| Title | Relationship between Carotid Atherosclerosis and Plasma Endothelin-1 Concentration in Senile Patients with Hypertension |
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