Risk of First Onset Stroke in SSRI-Exposed Adult Subjects: Survival Analysis and Examination of Age and Time Effects

• Published in: The journal of clinical psychiatry Vol. 78; no. 8; p. e1006
• Main Authors: Chan, Chin-Hong, Huang, Hsiang-Hsiung, Lin, Ching-Heng, Kuan, Yi-Chun, Loh, El-Wui, Lan, Tsuo-Hung
• Format: Journal Article
• Language: English
• Published: United States 01.09.2017
• Subjects: Adult; Age Factors; Aged; Brain Ischemia - diagnosis; Brain Ischemia - epidemiology; Brain Ischemia - etiology; Databases, Factual; Female; Humans; Incidence; Intracranial Hemorrhages - diagnosis; Intracranial Hemorrhages - epidemiology; Intracranial Hemorrhages - etiology; Kaplan-Meier Estimate; Male; Mental Disorders - drug therapy; Middle Aged; Retrospective Studies; Risk Assessment; Risk Factors; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - adverse effects; Stroke - diagnosis; Stroke - epidemiology; Stroke - etiology; Survival Analysis; Taiwan - epidemiology; Time Factors

Exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to increase the risk of stroke. In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects. We analyzed an 8-year cohort from the National Health Insurance R...