Calystegines in Solanum lycocarpum and Other Wild Solanum Fruits and Their α-Glucosidase Inhibitory Activity

The present work aims to investigate the α-glucosidase inhibitory activity displayed by calystegine-enriched extracts from fruits of the following wild Solanum species: S. lycocarpum A.St.-Hil., S. paniculatum L., S. crinitum Lam ., and S. acanthodes Hook.f., Solanaceae. Plant crude extracts were lo...

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Published inRevista brasileira de farmacognosia Vol. 32; no. 2; pp. 286 - 290
Main Authors Souto, Luís Fernando Lira, de Oliveira, George Azevedo, da Silva, Antonio Jorge Ribeiro
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.04.2022
Subjects
Medicine
Pharmacy
Short Communication
Medicinal plants
Iminosugar
Glycoside hydrolases
Edible plants
Hydrolase inhibitor
Sugar-mimicking structures
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Summary:The present work aims to investigate the α-glucosidase inhibitory activity displayed by calystegine-enriched extracts from fruits of the following wild Solanum species: S. lycocarpum A.St.-Hil., S. paniculatum L., S. crinitum Lam ., and S. acanthodes Hook.f., Solanaceae. Plant crude extracts were loaded on an ion-exchange resin separation system to obtain extracts enriched in calystegines. The inhibitory activities of the total calystegine extracts against Saccharomyces cerevisiae α-glucosidase were measured spectrophotometrically. Analyses were performed by gas chromatography coupled with mass spectrometry, and gas chromatography with flame ionization detection. All extracts exhibited inhibitory activities against α-glucosidase from S. cerevisiae . Calystegines A 3 , B 1 , B 2 , and C 1 were detected in all extracts. Graphical abstract
ISSN:1981-528X
1981-528X
DOI:10.1007/s43450-022-00232-2