Synthesis and Characterization of D-α-Tocopheryl Polyethylene Glycol 1000 Succinate-Block-Poly (ϵ-caprolactone) Copolymer Used as Carriers for Microparticles

A novel copolymer, D- α -tocopheryl polyethylene glycol 1000 succinate-block-Poly ( ε -caprolactone) (TPGS-block-PCL), was synthesized and characterized by 1 H-NMR and FTIR. The molecular weight was determined by gel permeation chromatography. TPGS-block-PCL can be used to prepare microparticles for...

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Published inJournal of dispersion science and technology Vol. 30; no. 8; pp. 1129 - 1134
Main Authors Ren, Fuzheng, Jing, Qiufang, Cui, Jingbin, Shen, Yongjia
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis 01.09.2009
Subjects
Chemistry
Colloidal state and disperse state
Copolymer
D-α-tocopheryl polyethylene glycol 1000 succinate
Exact sciences and technology
General and physical chemistry
microparticle
Physical and chemical studies. Granulometry. Electrokinetic phenomena
poly (ϵ-caprolactone)
Encapsulation
Particle size
NMR spectrometry
Emulsifier
Solvent extraction
Characterization
Ethylene oxide polymer
Synthesis
Efficiency
Microparticle
Copolymer
Molecular mass
Release
Drug
Delivery system
Scanning electron microscopy
D-α-tocopheryl polyethylene glycol 1000 succinate
Light scattering
Evaporation
Method
In vitro
Gel permeation chromatography
Infrared spectrometry
Morphology
Laser
poly
caprolactone
Block copolymer
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Abstract A novel copolymer, D- α -tocopheryl polyethylene glycol 1000 succinate-block-Poly ( ε -caprolactone) (TPGS-block-PCL), was synthesized and characterized by 1 H-NMR and FTIR. The molecular weight was determined by gel permeation chromatography. TPGS-block-PCL can be used to prepare microparticles for drug delivery system by a modified solvent extraction/evaporation method without extra emulsifier. The risperidone-loaded microparticles were characterized by laser light scattering for particle size and by scanning electron microscopy (SEM) for surface morphology. The drug encapsulation efficiency and the in vitro drug release profiles were measured. A significantly higher drug release rate was observed for microparticles with TPGS-block-PCL copolymer than PCL.
AbstractList A novel copolymer, D- α -tocopheryl polyethylene glycol 1000 succinate-block-Poly ( ε -caprolactone) (TPGS-block-PCL), was synthesized and characterized by 1 H-NMR and FTIR. The molecular weight was determined by gel permeation chromatography. TPGS-block-PCL can be used to prepare microparticles for drug delivery system by a modified solvent extraction/evaporation method without extra emulsifier. The risperidone-loaded microparticles were characterized by laser light scattering for particle size and by scanning electron microscopy (SEM) for surface morphology. The drug encapsulation efficiency and the in vitro drug release profiles were measured. A significantly higher drug release rate was observed for microparticles with TPGS-block-PCL copolymer than PCL.
Author Cui, Jingbin
Jing, Qiufang
Shen, Yongjia
Ren, Fuzheng
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Issue 8
Keywords Encapsulation
Particle size
NMR spectrometry
Emulsifier
Solvent extraction
Characterization
Ethylene oxide polymer
Synthesis
Efficiency
Microparticle
Copolymer
Molecular mass
Release
Drug
Delivery system
Scanning electron microscopy
D-α-tocopheryl polyethylene glycol 1000 succinate
Light scattering
Evaporation
Method
In vitro
Gel permeation chromatography
Infrared spectrometry
Morphology
Laser
poly
caprolactone
Block copolymer
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Snippet A novel copolymer, D- α -tocopheryl polyethylene glycol 1000 succinate-block-Poly ( ε -caprolactone) (TPGS-block-PCL), was synthesized and characterized by 1...
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SubjectTerms Chemistry
Colloidal state and disperse state
Copolymer
D-α-tocopheryl polyethylene glycol 1000 succinate
Exact sciences and technology
General and physical chemistry
microparticle
Physical and chemical studies. Granulometry. Electrokinetic phenomena
poly (ϵ-caprolactone)
Title Synthesis and Characterization of D-α-Tocopheryl Polyethylene Glycol 1000 Succinate-Block-Poly (ϵ-caprolactone) Copolymer Used as Carriers for Microparticles
URI https://www.tandfonline.com/doi/abs/10.1080/01932690802701507
Volume 30
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