Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication

• Published in: Journal of general virology Vol. 98; no. 6; pp. 1467 - 1476
• Main Authors: Wang, Jiang, Zeng, Lei, Zhang, Li, Guo, Zhen-Zhen, Lu, Shao-Fang, Ming, Sheng-Li, Li, Guo-Li, Wan, Bo, Tian, Ke-Gong, Yang, Guo-Yu, Chu, Bei-Bei
• Format: Journal Article
• Language: English
• Published: England 01.06.2017
• Subjects: Animals; Antiviral Agents - metabolism; Cells, Cultured; Herpesvirus 1, Suid - growth & development; Herpesvirus 1, Suid - immunology; Host-Pathogen Interactions; Hydroxycholesterols - metabolism; Immunity, Innate; Macrophages, Alveolar - immunology; Macrophages, Alveolar - virology; Steroid Hydroxylases - metabolism; Swine; Virus Attachment - drug effects; Virus Internalization - drug effects; Virus Replication

Cholesterol 25-hydroxylase (CH25H) catalyses the production of 25-hydroxycholesterol (25HC) from cholesterol by adding a second hydroxyl group at position 25. The aim of this study was to examine the antiviral effect of CH25H on pseudorabies virus (PRV), a swine pathogen that can cause devastating d...