PLLA scaffolds functionalized with ketoprofen via rotary jet spinning for biomedical applications

Biopolymer-based biomaterials, such as poly (l-lactic acid) (PLLA), have long been recognized as scaffolds for drug delivery applications due to their advantages, including biodegradability and biocompatibility. Ketoprofen (KET) is a non-steroidal anti-inflammatory drug known for its analgesic prope...

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Published inJournal of materials research and technology Vol. 30; pp. 9020 - 9027
Main Authors Dantas, Flávio Lopes, Rodriguez Llanos, Jaiber Humberto, Pereira Rodrigues, Isabella Caroline, Pereira, Karina Danielle, Luchessi, Augusto Ducati, Sawazaki, Renato, Najar Lopes, Éder Sócrates, Gabriel, Laís Pellizzer
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.05.2024
Elsevier
Subjects
Bio-carriers
Biomaterials
Centrifugal spinning
Tissue engineering
Bio-carriers
Centrifugal spinning
Tissue engineering
Biomaterials
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Abstract Biopolymer-based biomaterials, such as poly (l-lactic acid) (PLLA), have long been recognized as scaffolds for drug delivery applications due to their advantages, including biodegradability and biocompatibility. Ketoprofen (KET) is a non-steroidal anti-inflammatory drug known for its analgesic properties. Despite its potential, more research is needed on the effective production of scaffolds functionalized with KET for biomedical applications. This study, therefore, aimed to develop PLLA-based carriers to transport KET obtained using Rotary Jet Spinning (RJS) and evaluate the influence of KET at different concentrations. RJS allowed PLLA-KET scaffold production with high productivity and uniform fiber morphology. KET particles dispersed in the PLLA fibers were observed through scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Furthermore, the Fourier Transform Infrared Spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed the presence of KET in the PLLA and that the crystalline structure of PLLA remained unchanged with the incorporation of KET, ensuring the material's structural integrity. Likewise, the thermogravimetric analysis showed the presence of KET affected the thermal stability of PLLA. Cell viability and confocal microscopy with preosteoblast cells demonstrated that PLLA-KET fibers maintained cell viability over time, indicating their compatibility with cell cultures, and revealed cell adhesion and distribution in the fibers varied with KET concentration. These results have significant implications, highlighting the potential use of PLLA-KET carriers in practical biomedical applications, such as drug delivery systems, bone implant devices, and dental applications, thereby advancing the field of biomaterials.
AbstractList Biopolymer-based biomaterials, such as poly (l-lactic acid) (PLLA), have long been recognized as scaffolds for drug delivery applications due to their advantages, including biodegradability and biocompatibility. Ketoprofen (KET) is a non-steroidal anti-inflammatory drug known for its analgesic properties. Despite its potential, more research is needed on the effective production of scaffolds functionalized with KET for biomedical applications. This study, therefore, aimed to develop PLLA-based carriers to transport KET obtained using Rotary Jet Spinning (RJS) and evaluate the influence of KET at different concentrations. RJS allowed PLLA-KET scaffold production with high productivity and uniform fiber morphology. KET particles dispersed in the PLLA fibers were observed through scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Furthermore, the Fourier Transform Infrared Spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed the presence of KET in the PLLA and that the crystalline structure of PLLA remained unchanged with the incorporation of KET, ensuring the material's structural integrity. Likewise, the thermogravimetric analysis showed the presence of KET affected the thermal stability of PLLA. Cell viability and confocal microscopy with preosteoblast cells demonstrated that PLLA-KET fibers maintained cell viability over time, indicating their compatibility with cell cultures, and revealed cell adhesion and distribution in the fibers varied with KET concentration. These results have significant implications, highlighting the potential use of PLLA-KET carriers in practical biomedical applications, such as drug delivery systems, bone implant devices, and dental applications, thereby advancing the field of biomaterials.
Author Luchessi, Augusto Ducati
Pereira Rodrigues, Isabella Caroline
Dantas, Flávio Lopes
Sawazaki, Renato
Najar Lopes, Éder Sócrates
Pereira, Karina Danielle
Gabriel, Laís Pellizzer
Rodriguez Llanos, Jaiber Humberto
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  givenname: Renato
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  email: lgabriel@unicamp.br
  organization: Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Aplicadas (FCA), Limeira, São Paulo, Brazil
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Centrifugal spinning
Tissue engineering
Biomaterials
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Snippet Biopolymer-based biomaterials, such as poly (l-lactic acid) (PLLA), have long been recognized as scaffolds for drug delivery applications due to their...
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SubjectTerms Bio-carriers
Biomaterials
Centrifugal spinning
Tissue engineering
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Title PLLA scaffolds functionalized with ketoprofen via rotary jet spinning for biomedical applications
URI https://dx.doi.org/10.1016/j.jmrt.2024.05.206
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