CD56brightCD16- Killer Ig-Like Receptor- NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation
Human NK cells can be divided into CD56(dim)CD16(+) killer Ig-like receptors (KIR)(+/-) and CD56(bright)CD16(-) KIR(-) subsets that have been characterized extensively regarding their different functions, phenotype, and tissue localization. Nonetheless, the developmental relationship between these t...
Saved in:
| Published in | The Journal of immunology (1950) Vol. 178; no. 8; pp. 4947 - 4955 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Am Assoc Immnol
15.04.2007
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Human NK cells can be divided into CD56(dim)CD16(+) killer Ig-like receptors (KIR)(+/-) and CD56(bright)CD16(-) KIR(-) subsets that have been characterized extensively regarding their different functions, phenotype, and tissue localization. Nonetheless, the developmental relationship between these two NK cell subsets remains controversial. We report that, upon cytokine activation, peripheral blood (PB)-CD56(bright) NK cells mainly gain the signature of CD56(dim) NK cells. Remarkably, KIR can be induced not only on CD56(bright), but also on CD56(dim) KIR(-) NK cells, and their expression correlates with lower proliferative response. In addition, we demonstrate for the first time that PB-CD56(dim) display shorter telomeres than PB- and lymph node (LN)-derived CD56(bright) NK cells. Along this line, although human NK cells collected from nonreactive LN display almost no KIR and CD16 expression, NK cells derived from highly reactive LN, efferent lymph, and PB express significant amounts of KIR and CD16, implying that CD56(bright) NK cells could acquire these molecules in the LN during inflammation and then circulate through the efferent lymph into PB as KIR(+)CD16(+) NK cells. Altogether, our results suggest that CD56(bright)CD16(-) KIR(-) and CD56(dim)CD16(+)KIR(+/-) NK cells correspond to sequential steps of differentiation and support the hypothesis that secondary lymphoid organs can be sites of NK cell final maturation and self-tolerance acquisition during immune reaction. |
|---|---|
| AbstractList | Human NK cells can be divided into CD56(dim)CD16(+) killer Ig-like receptors (KIR)(+/-) and CD56(bright)CD16(-) KIR(-) subsets that have been characterized extensively regarding their different functions, phenotype, and tissue localization. Nonetheless, the developmental relationship between these two NK cell subsets remains controversial. We report that, upon cytokine activation, peripheral blood (PB)-CD56(bright) NK cells mainly gain the signature of CD56(dim) NK cells. Remarkably, KIR can be induced not only on CD56(bright), but also on CD56(dim) KIR(-) NK cells, and their expression correlates with lower proliferative response. In addition, we demonstrate for the first time that PB-CD56(dim) display shorter telomeres than PB- and lymph node (LN)-derived CD56(bright) NK cells. Along this line, although human NK cells collected from nonreactive LN display almost no KIR and CD16 expression, NK cells derived from highly reactive LN, efferent lymph, and PB express significant amounts of KIR and CD16, implying that CD56(bright) NK cells could acquire these molecules in the LN during inflammation and then circulate through the efferent lymph into PB as KIR(+)CD16(+) NK cells. Altogether, our results suggest that CD56(bright)CD16(-) KIR(-) and CD56(dim)CD16(+)KIR(+/-) NK cells correspond to sequential steps of differentiation and support the hypothesis that secondary lymphoid organs can be sites of NK cell final maturation and self-tolerance acquisition during immune reaction. Abstract Human NK cells can be divided into CD56dimCD16+ killer Ig-like receptors (KIR)+/− and CD56brightCD16− KIR− subsets that have been characterized extensively regarding their different functions, phenotype, and tissue localization. Nonetheless, the developmental relationship between these two NK cell subsets remains controversial. We report that, upon cytokine activation, peripheral blood (PB)-CD56bright NK cells mainly gain the signature of CD56dim NK cells. Remarkably, KIR can be induced not only on CD56bright, but also on CD56dim KIR− NK cells, and their expression correlates with lower proliferative response. In addition, we demonstrate for the first time that PB-CD56dim display shorter telomeres than PB- and lymph node (LN)-derived CD56bright NK cells. Along this line, although human NK cells collected from nonreactive LN display almost no KIR and CD16 expression, NK cells derived from highly reactive LN, efferent lymph, and PB express significant amounts of KIR and CD16, implying that CD56bright NK cells could acquire these molecules in the LN during inflammation and then circulate through the efferent lymph into PB as KIR+CD16+ NK cells. Altogether, our results suggest that CD56brightCD16− KIR− and CD56dimCD16+KIR+/− NK cells correspond to sequential steps of differentiation and support the hypothesis that secondary lymphoid organs can be sites of NK cell final maturation and self-tolerance acquisition during immune reaction. |
| Author | Moretta, Lorenzo Romagnani, Chiara Lui, Gabrielle Moretta, Alessandro D'Agostino, Antonella Juelke, Kerstin Thiel, Andreas Costa, Roberta Falco, Michela Strowig, Till Ferlazzo, Guido Carrega, Paolo Forte, Giuseppe Ratto, Giovanni Munz, Christian Morandi, Barbara Conte, Romana |
| Author_xml | – sequence: 1 fullname: Romagnani, Chiara – sequence: 2 fullname: Juelke, Kerstin – sequence: 3 fullname: Falco, Michela – sequence: 4 fullname: Morandi, Barbara – sequence: 5 fullname: D'Agostino, Antonella – sequence: 6 fullname: Costa, Roberta – sequence: 7 fullname: Ratto, Giovanni – sequence: 8 fullname: Forte, Giuseppe – sequence: 9 fullname: Carrega, Paolo – sequence: 10 fullname: Lui, Gabrielle – sequence: 11 fullname: Conte, Romana – sequence: 12 fullname: Strowig, Till – sequence: 13 fullname: Moretta, Alessandro – sequence: 14 fullname: Munz, Christian – sequence: 15 fullname: Thiel, Andreas – sequence: 16 fullname: Moretta, Lorenzo – sequence: 17 fullname: Ferlazzo, Guido |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17404276$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkE1P3DAQQK2KqizQX4CEfGpP2dpJbCdHlC0fYtVKiJ4txxkvpk4c7IQVZ_44Xu1W9GRp9OaN9U7Q0eAHQOickmVJyvrHk-37efBuSUW1rJZlXYpPaEEZIxnnhB-hBSF5nlHBxTE6ifGJEMJJXn5Bx1QkQy74Ar01K8bbYDePU7OiPMN31jkI-HaTre1fwPegYZx8yPCvO9yAcxGvbBydesVrP2wS-QDO9xAgYjV0-FI_zzYAvgI1zbuhN3h3orP9h2Ee_ZDIyb6oyfrhDH02ykX4enhP0Z-rnw_NTbb-fX3bXK4znddUZEVdGd1pwZTiQhtgHa9UIXgrWsa0JkVuTA2U16XuKtOWuoKSEW4oZ3UhRF2com977xj88wxxkr2NOv1IDeDnKAUpCkYZTWCxB3XwMQYwcgy2V-FVUiJ37eW_9jK1l5XctU9bFwf93PbQfewcYifg-x54TLm3qZKMvXIu4VRut9v_VO_vvJBf |
| CitedBy_id | crossref_primary_10_1002_imed_1027 crossref_primary_10_3109_07853890_2011_554430 crossref_primary_10_1159_000365632 crossref_primary_10_1038_nri2935 crossref_primary_10_1002_eji_201242382 crossref_primary_10_3390_cancers13071589 crossref_primary_10_3390_v15020323 crossref_primary_10_4049_jimmunol_1100330 crossref_primary_10_3389_fimmu_2021_772332 crossref_primary_10_1007_s12272_017_0951_9 crossref_primary_10_1038_icb_2009_91 crossref_primary_10_1038_s41598_022_18413_3 crossref_primary_10_1097_CMR_0000000000000126 crossref_primary_10_1590_1806_9282_20230872 crossref_primary_10_1097_PAT_0000000000000275 crossref_primary_10_2147_BTT_S290305 crossref_primary_10_1093_jnci_dju200 crossref_primary_10_1155_2010_732893 crossref_primary_10_1016_j_micinf_2012_05_001 crossref_primary_10_1016_j_radmeas_2010_07_028 crossref_primary_10_1146_annurev_immunol_101819_074948 crossref_primary_10_1182_blood_2010_02_270678 crossref_primary_10_1016_j_celrep_2019_12_096 crossref_primary_10_1016_j_jhep_2013_03_003 crossref_primary_10_1182_blood_2010_04_281675 crossref_primary_10_1016_j_vetimm_2009_02_017 crossref_primary_10_1089_aid_2019_0134 crossref_primary_10_1111_sji_12455 crossref_primary_10_3389_fcell_2022_907572 crossref_primary_10_3389_fimmu_2014_00282 crossref_primary_10_1016_j_jaci_2020_12_648 crossref_primary_10_1038_mi_2015_47 crossref_primary_10_1371_journal_pone_0080131 crossref_primary_10_1016_j_coi_2014_04_002 crossref_primary_10_1093_intimm_dxq463 crossref_primary_10_1182_blood_2011_08_372003 crossref_primary_10_1016_j_jhep_2010_05_013 crossref_primary_10_1111_imr_12725 crossref_primary_10_1111_imm_12708 crossref_primary_10_1016_j_bioactmat_2024_02_031 crossref_primary_10_4049_jimmunol_179_9_5977 crossref_primary_10_1371_journal_ppat_1006999 crossref_primary_10_1371_journal_ppat_1005421 crossref_primary_10_1002_ajh_21906 crossref_primary_10_1182_blood_2009_11_253286 crossref_primary_10_1155_2011_316314 crossref_primary_10_1007_s11427_015_4970_9 crossref_primary_10_1080_2162402X_2017_1293210 crossref_primary_10_1002_eji_200838849 crossref_primary_10_3390_ijms18091868 crossref_primary_10_1189_jlb_0111007 crossref_primary_10_3389_fimmu_2015_00601 crossref_primary_10_1007_s00262_011_1067_6 crossref_primary_10_1134_S1068162016060066 crossref_primary_10_1016_j_jss_2013_02_025 crossref_primary_10_1111_cei_12849 crossref_primary_10_3390_biom14040456 crossref_primary_10_3390_biom12010068 crossref_primary_10_1111_j_1600_065X_2007_00563_x crossref_primary_10_1182_blood_2006_10_048173 crossref_primary_10_4049_jimmunol_1501783 crossref_primary_10_3389_fimmu_2019_01503 crossref_primary_10_1007_s10875_023_01437_3 crossref_primary_10_3389_fimmu_2019_02836 crossref_primary_10_1371_journal_ppat_1002268 crossref_primary_10_3389_fendo_2020_00406 crossref_primary_10_1016_j_it_2019_08_005 crossref_primary_10_1016_j_smim_2022_101670 crossref_primary_10_3389_fimmu_2022_910595 crossref_primary_10_1089_scd_2011_0659 crossref_primary_10_1182_blood_2010_04_282301 crossref_primary_10_1007_s12253_018_0444_2 crossref_primary_10_1172_JCI86276 crossref_primary_10_3390_ijms22169044 crossref_primary_10_3389_fimmu_2019_01179 crossref_primary_10_3389_fimmu_2020_02117 crossref_primary_10_1002_eji_201041361 crossref_primary_10_1002_cti2_1244 crossref_primary_10_1016_j_jhep_2019_03_012 crossref_primary_10_1016_j_imlet_2014_06_015 crossref_primary_10_1080_08820139_2017_1402925 crossref_primary_10_1172_jci_insight_154948 crossref_primary_10_1186_s12943_023_01737_7 crossref_primary_10_1002_eji_201344072 crossref_primary_10_3390_cancers13020320 crossref_primary_10_3389_fonc_2022_1004871 crossref_primary_10_1016_j_clim_2010_06_002 crossref_primary_10_1371_journal_pone_0158827 crossref_primary_10_1016_j_molonc_2015_10_001 crossref_primary_10_3389_fimmu_2022_914266 crossref_primary_10_3390_ijms20020317 crossref_primary_10_4161_onci_26688 crossref_primary_10_1007_s00262_020_02811_5 crossref_primary_10_1111_j_1365_2567_2008_03027_x crossref_primary_10_1038_leu_2010_149 crossref_primary_10_1111_j_1365_3083_2007_01980_x crossref_primary_10_1586_eci_12_71 crossref_primary_10_1016_j_it_2013_07_005 crossref_primary_10_1097_CJI_0b013e3181bb46f7 crossref_primary_10_4049_jimmunol_2000212 crossref_primary_10_1172_JCI85413 crossref_primary_10_3389_fimmu_2019_01124 crossref_primary_10_1016_j_humpath_2014_04_024 crossref_primary_10_1182_blood_2009_05_222265 crossref_primary_10_1016_j_leukres_2013_09_005 crossref_primary_10_1111_imm_12925 crossref_primary_10_1182_blood_2007_07_103325 crossref_primary_10_1309_AJCPWGG69MCZOWMM crossref_primary_10_1007_s00262_009_0724_5 crossref_primary_10_1038_nri_2016_34 crossref_primary_10_1016_j_cellimm_2011_06_026 crossref_primary_10_1016_j_immuni_2017_10_008 crossref_primary_10_1155_2013_935295 crossref_primary_10_1002_biof_107 crossref_primary_10_1016_j_imlet_2017_08_014 crossref_primary_10_1016_j_celrep_2016_05_095 crossref_primary_10_1158_1078_0432_CCR_13_2302 crossref_primary_10_3389_fimmu_2016_00545 crossref_primary_10_3389_fimmu_2022_888313 crossref_primary_10_1097_CCO_0b013e328335a559 crossref_primary_10_3390_ijms23179880 crossref_primary_10_1038_s41467_021_21878_x crossref_primary_10_18632_aging_101774 crossref_primary_10_1016_j_dci_2007_11_006 crossref_primary_10_1111_j_1365_2567_2011_03410_x crossref_primary_10_3390_cancers10120473 crossref_primary_10_1002_cyto_b_21508 crossref_primary_10_1002_eji_201344130 crossref_primary_10_1371_journal_pone_0087131 crossref_primary_10_1016_j_biopha_2010_06_013 crossref_primary_10_1155_2011_986491 crossref_primary_10_1016_j_intimp_2018_09_016 crossref_primary_10_1016_j_imlet_2013_12_009 crossref_primary_10_1016_j_smim_2019_03_001 crossref_primary_10_1002_eji_201445208 crossref_primary_10_1002_eji_200940016 crossref_primary_10_1128_JVI_01546_15 crossref_primary_10_1016_j_imlet_2010_11_001 crossref_primary_10_3389_fimmu_2017_00868 crossref_primary_10_4049_jimmunol_2000430 crossref_primary_10_1038_s41598_024_63103_x crossref_primary_10_1002_cyto_a_20893 crossref_primary_10_1186_s12974_024_03040_8 crossref_primary_10_3389_fimmu_2019_02235 crossref_primary_10_1093_intimm_dxp046 crossref_primary_10_3390_cancers12061553 crossref_primary_10_1002_eji_200838882 crossref_primary_10_1038_gene_2012_62 crossref_primary_10_3390_cancers14102483 crossref_primary_10_1016_j_jaci_2022_09_022 crossref_primary_10_1186_1471_2172_10_50 crossref_primary_10_1038_s41423_020_00574_8 crossref_primary_10_1038_sj_cdd_4402170 crossref_primary_10_1002_eji_201747128 crossref_primary_10_1073_pnas_1012356108 crossref_primary_10_1007_s13273_019_00059_4 crossref_primary_10_1016_j_vetmic_2013_01_042 crossref_primary_10_3389_fimmu_2016_00402 crossref_primary_10_1016_j_clim_2011_09_006 crossref_primary_10_1016_j_immuni_2010_06_007 crossref_primary_10_1158_2326_6066_CIR_14_0054_T crossref_primary_10_1002_eji_201343868 crossref_primary_10_1016_j_cytogfr_2018_03_008 crossref_primary_10_1016_j_fsi_2024_109415 crossref_primary_10_1002_cyto_a_22025 crossref_primary_10_1155_2022_9218640 crossref_primary_10_3389_fimmu_2022_1044398 crossref_primary_10_1189_jlb_0907650 crossref_primary_10_1038_nri3065 crossref_primary_10_3389_fimmu_2019_01812 crossref_primary_10_1038_s41598_017_03256_0 crossref_primary_10_1002_eji_202048696 crossref_primary_10_1016_j_jaci_2017_06_039 crossref_primary_10_1182_blood_2008_03_143727 crossref_primary_10_3109_1547691X_2013_877104 crossref_primary_10_1371_journal_pone_0030264 crossref_primary_10_1016_j_virusres_2017_04_001 crossref_primary_10_1097_QAD_0b013e3282f08b72 crossref_primary_10_1111_imr_12071 crossref_primary_10_3389_fimmu_2018_02360 crossref_primary_10_1182_blood_2009_04_215491 crossref_primary_10_1007_s10875_009_9283_y crossref_primary_10_1016_j_dld_2016_01_008 crossref_primary_10_4049_jimmunol_180_8_5746 crossref_primary_10_1007_s11904_008_0008_2 crossref_primary_10_1182_blood_2008_07_166389 crossref_primary_10_1038_ncomms9109 crossref_primary_10_1016_j_intimp_2022_108783 crossref_primary_10_4049_jimmunol_1002732 crossref_primary_10_2217_hiv_10_28 crossref_primary_10_1002_eji_200939910 crossref_primary_10_1016_j_it_2011_06_013 crossref_primary_10_3390_microorganisms8070989 crossref_primary_10_1155_2015_839684 crossref_primary_10_1158_2159_8290_CD_20_0655 crossref_primary_10_1172_JCI61014 crossref_primary_10_1091_mbc_E19_08_0424 crossref_primary_10_3389_fimmu_2017_00293 crossref_primary_10_3389_fimmu_2022_852436 crossref_primary_10_1016_j_bbmt_2014_01_006 crossref_primary_10_1038_ncomms6639 crossref_primary_10_1097_ACI_0000000000000317 crossref_primary_10_1007_s00262_015_1750_0 crossref_primary_10_3389_fimmu_2024_1343929 crossref_primary_10_4049_jimmunol_1301046 crossref_primary_10_4049_jimmunol_1801475 crossref_primary_10_1111_tan_13509 crossref_primary_10_1080_21505594_2021_1939608 crossref_primary_10_4049_jimmunol_1001637 crossref_primary_10_1038_s41392_022_01058_z crossref_primary_10_1002_cncr_23239 crossref_primary_10_3389_fimmu_2015_00567 crossref_primary_10_3389_fimmu_2019_02794 crossref_primary_10_1371_journal_pone_0011966 crossref_primary_10_4049_jimmunol_181_3_2227 crossref_primary_10_1002_JLB_MR0718_300R crossref_primary_10_1016_j_humimm_2013_08_281 crossref_primary_10_1007_s10637_019_00885_2 crossref_primary_10_1038_s41598_018_21443_5 crossref_primary_10_1016_j_semcancer_2015_12_002 crossref_primary_10_1161_ATVBAHA_111_233288 crossref_primary_10_3389_fimmu_2017_00025 crossref_primary_10_3389_fimmu_2017_00268 crossref_primary_10_1111_j_1365_2567_2008_02887_x crossref_primary_10_3389_fcell_2020_00119 crossref_primary_10_4049_jimmunol_1301625 crossref_primary_10_1111_aji_13101 crossref_primary_10_1002_ijc_31213 crossref_primary_10_1186_s12967_024_05033_w crossref_primary_10_1111_imcb_1032 crossref_primary_10_1016_j_smim_2014_02_003 crossref_primary_10_1016_j_immuni_2018_09_009 crossref_primary_10_1002_JLB_3MR0820_685R crossref_primary_10_1111_j_1474_9726_2010_00584_x crossref_primary_10_1182_blood_2007_09_077438 crossref_primary_10_1002_cyto_a_24001 crossref_primary_10_1038_embor_2009_203 crossref_primary_10_1182_blood_2010_03_275438 crossref_primary_10_4049_jimmunol_0803323 crossref_primary_10_1016_j_smim_2014_02_008 crossref_primary_10_1111_j_1600_6143_2011_03617_x crossref_primary_10_3389_fimmu_2018_02324 crossref_primary_10_1182_bloodadvances_2019000953 crossref_primary_10_1002_eji_201242752 crossref_primary_10_3389_fimmu_2017_00277 crossref_primary_10_1002_eji_201141760 crossref_primary_10_3389_fimmu_2015_00583 crossref_primary_10_3390_molecules25235686 crossref_primary_10_4049_jimmunol_0901226 crossref_primary_10_1016_j_ebiom_2023_104811 crossref_primary_10_3389_fimmu_2014_00258 crossref_primary_10_3389_fimmu_2018_01429 crossref_primary_10_1186_s40064_016_1884_3 crossref_primary_10_1002_iid3_179 crossref_primary_10_3389_fimmu_2017_00360 crossref_primary_10_1016_j_jaci_2018_06_047 crossref_primary_10_1016_j_clim_2011_03_007 crossref_primary_10_3390_ph14030236 crossref_primary_10_3389_fimmu_2021_622306 crossref_primary_10_1002_jcp_28657 crossref_primary_10_1007_s00018_011_0799_y crossref_primary_10_1093_brain_awn132 crossref_primary_10_1016_j_stem_2014_03_006 crossref_primary_10_1093_jleuko_qiad027 crossref_primary_10_4049_jimmunol_1301889 crossref_primary_10_1111_j_1399_3038_2010_01136_x crossref_primary_10_1371_journal_pone_0164517 crossref_primary_10_1371_journal_pone_0051677 crossref_primary_10_1080_2162402X_2015_1041701 crossref_primary_10_3389_fimmu_2016_00262 crossref_primary_10_1084_jem_20082013 crossref_primary_10_1182_blood_2011_09_379693 crossref_primary_10_3389_fimmu_2020_01484 crossref_primary_10_4049_jimmunol_1502603 crossref_primary_10_1074_mcp_M112_024596 crossref_primary_10_1016_j_molimm_2008_01_001 crossref_primary_10_1172_JCI134966 crossref_primary_10_3389_fimmu_2018_02743 crossref_primary_10_4049_jimmunol_1200140 crossref_primary_10_1158_0008_5472_CAN_13_1303 crossref_primary_10_1016_j_immuni_2016_04_007 crossref_primary_10_3389_fimmu_2021_683381 crossref_primary_10_1172_JCI45816 crossref_primary_10_1155_2011_251679 crossref_primary_10_3389_fimmu_2017_00930 crossref_primary_10_1038_ni_3482 crossref_primary_10_1182_blood_2009_08_238469 crossref_primary_10_1186_s12935_018_0644_6 crossref_primary_10_1016_j_humimm_2011_01_009 crossref_primary_10_1177_1753425912453187 crossref_primary_10_1002_eji_200939307 crossref_primary_10_1002_JLB_6RI0917_390R crossref_primary_10_1586_1744666X_4_1_79 crossref_primary_10_1182_blood_2011_11_392951 crossref_primary_10_1002_ijc_29962 crossref_primary_10_3389_fimmu_2017_00109 crossref_primary_10_3389_fimmu_2014_00159 crossref_primary_10_1016_j_tins_2014_02_010 crossref_primary_10_3389_fimmu_2019_02078 crossref_primary_10_1016_j_intimp_2024_111970 crossref_primary_10_1371_journal_pone_0061024 crossref_primary_10_3390_ijms22020911 crossref_primary_10_1080_2162402X_2017_1342024 crossref_primary_10_1016_j_jhep_2008_10_018 crossref_primary_10_4049_jimmunol_1400534 crossref_primary_10_1016_j_smim_2014_01_006 crossref_primary_10_1016_j_cyto_2019_02_001 crossref_primary_10_3389_fimmu_2017_01556 crossref_primary_10_1182_blood_2010_09_303057 crossref_primary_10_18632_oncotarget_5559 crossref_primary_10_3389_fimmu_2020_00812 crossref_primary_10_1182_blood_2011_12_398099 crossref_primary_10_1038_leu_2009_304 crossref_primary_10_3390_jcm9051450 crossref_primary_10_3389_fimmu_2019_02865 crossref_primary_10_1002_cyto_a_22302 crossref_primary_10_3389_fimmu_2018_01671 crossref_primary_10_1038_s41467_021_26187_x crossref_primary_10_1080_13547500902814658 crossref_primary_10_1111_j_1399_0039_2011_01714_x crossref_primary_10_1182_bloodadvances_2018030676 crossref_primary_10_1016_j_jinf_2010_05_004 crossref_primary_10_1111_imr_13324 crossref_primary_10_4049_jimmunol_180_12_7785 crossref_primary_10_1111_j_1365_2036_2010_04499_x crossref_primary_10_2217_imt_11_99 crossref_primary_10_1038_bmt_2009_89 crossref_primary_10_1002_eji_202049028 crossref_primary_10_1111_j_1365_2362_2010_02332_x crossref_primary_10_1097_ACI_0000000000000011 crossref_primary_10_1073_pnas_1112064108 crossref_primary_10_1155_2014_671087 |
| Cites_doi | 10.1016/j.immuni.2006.03.006 10.1016/S1471-4906(01)02113-5 10.1182/blood.V97.10.3146 10.1016/j.immuni.2005.01.013 10.1038/ni1043 10.1073/pnas.92.24.11091 10.1084/jem.183.2.645 10.4049/jimmunol.173.11.6547 10.1016/j.immuni.2006.06.013 10.4049/jimmunol.172.3.1455 10.1038/346866a0 10.1084/jem.20051474 10.1038/ni796 10.1038/nri1863 10.4049/jimmunol.173.10.6418 10.4049/jimmunol.175.5.2938 10.1016/S1471-4906(01)02060-9 10.1084/jem.20050128 10.1073/pnas.0407522101 10.1084/jem.20052507 10.1038/ni1138 10.1126/science.1068440 10.1038/6209 10.4049/jimmunol.166.11.6477 10.4049/jimmunol.175.10.6489 10.1002/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4 10.4049/jimmunol.172.1.88 10.1182/blood-2002-09-2876 10.1172/JCI116161 10.1038/nature03847 10.1002/eji.200526069 10.1182/blood-2004-08-3156 10.1002/eji.200425100 10.4049/jimmunol.169.8.4253 10.1016/j.molimm.2004.07.029 10.1038/nbt0898-743 10.1172/JCI6218 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.4049/jimmunol.178.8.4947 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1550-6606 |
| EndPage | 4955 |
| ExternalDocumentID | 10_4049_jimmunol_178_8_4947 17404276 www178_8_4947 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R01CA108609 |
| GroupedDBID | - 08R 2WC 34G 39C 3O- 53G 55 5GY 5RE 5VS 79B 85S 8RP AALRV AARDX ABEFU ABFLS ABOCM ABPPZ ABPTK ACGFS ACIWK ACNCT ACPRK ADACO ADBBV ADKFC AENEX AETEA AFFNX AFRAH AJYGW ALMA_UNASSIGNED_HOLDINGS BAWUL D0L DIK DU5 E3Z EBS EJD F5P FH7 FRP GX1 H13 IH2 J5H K-O K78 KQ8 L7B MVM MYA NEJ O0- OK1 P0W P2P PQEST PQQKQ R.V RHF RHI RZQ SJN TWZ WH7 WOQ X X7M XJT ZA5 ZE2 ZGI --- -~X .55 18M ABCQX ABJNI ACGFO ADNWM AFHIN AFOSN AHWXS AIZAD BTFSW CGR CUY CVF ECM EIF NPM TR2 W8F XSW XTH YHG AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c2917-398fcdc75aa67cfe5d68a376b7b55cc032ff9e1694cd8fb4c8e4506f165937793 |
| ISSN | 0022-1767 |
| IngestDate | Fri Oct 25 09:06:29 EDT 2024 Thu Sep 26 17:29:10 EDT 2024 Sat Sep 28 08:33:58 EDT 2024 Tue Nov 10 19:15:02 EST 2020 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c2917-398fcdc75aa67cfe5d68a376b7b55cc032ff9e1694cd8fb4c8e4506f165937793 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://journals.aai.org/jimmunol/article-pdf/178/8/4947/1240849/zim00807004947.pdf |
| PMID | 17404276 |
| PQID | 70335151 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_70335151 crossref_primary_10_4049_jimmunol_178_8_4947 pubmed_primary_17404276 highwire_smallpub1_www178_8_4947 |
| ProviderPackageCode | RHF RHI |
| PublicationCentury | 2000 |
| PublicationDate | 20070415 2007-Apr-15 2007-04-15 |
| PublicationDateYYYYMMDD | 2007-04-15 |
| PublicationDate_xml | – month: 04 year: 2007 text: 20070415 day: 15 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | The Journal of immunology (1950) |
| PublicationTitleAlternate | J Immunol |
| PublicationYear | 2007 |
| Publisher | Am Assoc Immnol |
| Publisher_xml | – name: Am Assoc Immnol |
| References | 2023010121263700600_R20 2023010121263700600_R10 2023010121263700600_R32 2023010121263700600_R11 2023010121263700600_R33 2023010121263700600_R12 2023010121263700600_R34 2023010121263700600_R13 2023010121263700600_R35 2023010121263700600_R14 2023010121263700600_R36 2023010121263700600_R15 2023010121263700600_R37 2023010121263700600_R16 2023010121263700600_R38 2023010121263700600_R17 2023010121263700600_R18 2023010121263700600_R19 2023010121263700600_R30 2023010121263700600_R31 2023010121263700600_R1 2023010121263700600_R21 2023010121263700600_R2 2023010121263700600_R22 2023010121263700600_R3 2023010121263700600_R23 2023010121263700600_R4 2023010121263700600_R24 2023010121263700600_R5 2023010121263700600_R25 2023010121263700600_R6 2023010121263700600_R26 2023010121263700600_R7 2023010121263700600_R27 2023010121263700600_R8 2023010121263700600_R28 2023010121263700600_R9 2023010121263700600_R29 |
| References_xml | – ident: 2023010121263700600_R22 doi: 10.1016/j.immuni.2006.03.006 – ident: 2023010121263700600_R29 doi: 10.1016/S1471-4906(01)02113-5 – ident: 2023010121263700600_R13 – ident: 2023010121263700600_R2 doi: 10.1182/blood.V97.10.3146 – ident: 2023010121263700600_R8 doi: 10.1016/j.immuni.2005.01.013 – ident: 2023010121263700600_R27 doi: 10.1038/ni1043 – ident: 2023010121263700600_R16 doi: 10.1073/pnas.92.24.11091 – ident: 2023010121263700600_R11 doi: 10.1084/jem.183.2.645 – ident: 2023010121263700600_R5 doi: 10.4049/jimmunol.173.11.6547 – ident: 2023010121263700600_R24 doi: 10.1016/j.immuni.2006.06.013 – ident: 2023010121263700600_R7 doi: 10.4049/jimmunol.172.3.1455 – ident: 2023010121263700600_R12 doi: 10.1038/346866a0 – ident: 2023010121263700600_R34 doi: 10.1084/jem.20051474 – ident: 2023010121263700600_R31 doi: 10.1038/ni796 – ident: 2023010121263700600_R23 doi: 10.1038/nri1863 – ident: 2023010121263700600_R35 doi: 10.4049/jimmunol.173.10.6418 – ident: 2023010121263700600_R25 doi: 10.4049/jimmunol.175.5.2938 – ident: 2023010121263700600_R4 doi: 10.1016/S1471-4906(01)02060-9 – ident: 2023010121263700600_R10 doi: 10.1084/jem.20050128 – ident: 2023010121263700600_R36 doi: 10.1073/pnas.0407522101 – ident: 2023010121263700600_R30 doi: 10.1084/jem.20052507 – ident: 2023010121263700600_R18 doi: 10.1038/ni1138 – ident: 2023010121263700600_R26 doi: 10.1126/science.1068440 – ident: 2023010121263700600_R15 doi: 10.1038/6209 – ident: 2023010121263700600_R3 doi: 10.4049/jimmunol.166.11.6477 – ident: 2023010121263700600_R17 doi: 10.4049/jimmunol.175.10.6489 – ident: 2023010121263700600_R1 doi: 10.1002/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4 – ident: 2023010121263700600_R9 doi: 10.4049/jimmunol.172.1.88 – ident: 2023010121263700600_R6 doi: 10.1182/blood-2002-09-2876 – ident: 2023010121263700600_R32 doi: 10.1172/JCI116161 – ident: 2023010121263700600_R20 doi: 10.1038/nature03847 – ident: 2023010121263700600_R37 doi: 10.1002/eji.200526069 – ident: 2023010121263700600_R21 doi: 10.1182/blood-2004-08-3156 – ident: 2023010121263700600_R38 doi: 10.1002/eji.200425100 – ident: 2023010121263700600_R19 doi: 10.4049/jimmunol.169.8.4253 – ident: 2023010121263700600_R28 doi: 10.1016/j.molimm.2004.07.029 – ident: 2023010121263700600_R14 doi: 10.1038/nbt0898-743 – ident: 2023010121263700600_R33 doi: 10.1172/JCI6218 |
| SSID | ssj0006024 |
| Score | 1.8885051 |
| Snippet | Human NK cells can be divided into CD56(dim)CD16(+) killer Ig-like receptors (KIR)(+/-) and CD56(bright)CD16(-) KIR(-) subsets that have been characterized... Abstract Human NK cells can be divided into CD56dimCD16+ killer Ig-like receptors (KIR)+/− and CD56brightCD16− KIR− subsets that have been characterized... |
| SourceID | proquest crossref pubmed highwire |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 4947 |
| SubjectTerms | CD56 Antigen - analysis Cells, Cultured Humans Hyperplasia Interleukin-12 - pharmacology Interleukin-15 - pharmacology Interleukin-2 - pharmacology Killer Cells, Natural - immunology Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation Receptors, IgG - analysis Receptors, Immunologic - analysis Receptors, KIR Self Tolerance Telomere |
| Title | CD56brightCD16- Killer Ig-Like Receptor- NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation |
| URI | http://www.jimmunol.org/cgi/content/abstract/178/8/4947 https://www.ncbi.nlm.nih.gov/pubmed/17404276 https://search.proquest.com/docview/70335151 |
| Volume | 178 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKEIgXBONWrn6Ap5AuVyd5RB1jrGof0Cb1LUoce6qWJlXbqBqv_BF-KufEzmXVJgEvURWndtzvq8859rkQ8tHNPJmCXWImrshML_S4GTqBZUYBSHfOMos5GOA8nbHTC-9s7s8Hg989r6Vqm474z1vjSv4HVbgHuGKU7D8g23YKN-Az4AtXQBiuf4Xx-NhnaW1ej49tZhpXdWCf8f3SzBdXWA8FfVbKtWnMJgbu0G_wPGaVJ9dGXtbhvluRl0sBFrfK2crRLVgYUtTZPmsnDxwiWyy7HqoV-i_zpipaX7ntwsxUJgoMPVEpnj7VB2lWb9vhR7lMLgtVUAr9QZJ1Kx_OKpErl6EJ6qaLlr4nSc7Lxtdf5O0XpkDjIlv0jk9u7GUEeCyjojl7sQV2oAp0tOtzEPaIGPZWWy9S2Tr3xYAHZg-KAT3PEfQwCkf7TwOWq2XNDLDKsOTIXkpuZSPppnvkvgNLGToNfpt3TkTMcrwmHz2-t8prheMf3TI6ZqjV_d1Ug5rU1HebObW6c_6EPNYw0i-KdE_JQBSH5IGqXHp9SB5OtU_GM_Jrj4VUsZBqFtKWhXQ2oTWHqGYhVSykLQspwEg1C2nDQlpKqlnY9YAspB0Ln5OLk6_n41NTl_YwuROBXuRGoeQZD_wkYQGXws9YmICsS4PU9zm3XEfKSNgs8ngWwmLCQ-H5FpM28yNMkem-IAdFWYhXhEJ7ltpcODySnoAJYwFt4VqpsKQVSWdIPje_dLxSGVxisHwRo7jBKAaM4jBGjIaENmjEm2WS54CCHe92u_4jHxqUYliMcd5JIcpqE4P4dMFAsIfkpQKvG1Hj_vrOljfkUfeXeEsOtutKvAOFd5u-rzn3B-95qUM |
| link.rule.ids | 315,783,787,27938,27939 |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CD56brightCD16-+killer+Ig-like+receptor-+NK+cells+display+longer+telomeres+and+acquire+features+of+CD56dim+NK+cells+upon+activation&rft.jtitle=The+Journal+of+immunology+%281950%29&rft.au=Romagnani%2C+Chiara&rft.au=Juelke%2C+Kerstin&rft.au=Falco%2C+Michela&rft.au=Morandi%2C+Barbara&rft.date=2007-04-15&rft.issn=0022-1767&rft.volume=178&rft.issue=8&rft.spage=4947&rft_id=info:doi/10.4049%2Fjimmunol.178.8.4947&rft_id=info%3Apmid%2F17404276&rft.externalDocID=17404276 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1767&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1767&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1767&client=summon |