Striato‐cortical connections in Parkinson's and Alzheimer's diseases: Relation to cognition
ABSTRACT Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting‐state striato‐cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mi...
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| Published in | Movement disorders Vol. 32; no. 6; pp. 917 - 922 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.06.2017
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| Abstract | ABSTRACT
Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease.
Objectives: The objective of this study was to evaluate resting‐state striato‐cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared.
Methods: Seed‐based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between‐group differences and clinical outcomes was assessed.
Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease.
Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society |
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| AbstractList | Functional connectivity is abnormal in PD and in early Alzheimer's disease.
The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared.
Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed.
Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease.
Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society. ABSTRACT Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting‐state striato‐cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed‐based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between‐group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society BACKGROUNDFunctional connectivity is abnormal in PD and in early Alzheimer's disease.OBJECTIVESThe objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared.METHODSSeed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed.RESULTSPatients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease.CONCLUSIONSStriatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society. |
| Author | Anderkova, Lubomira Rektorova, Irena Barton, Marek |
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| Keywords | resting state functional connectivity Parkinson's disease cognition striatum Alzheimer's disease |
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| Notes | Nothing to report. Relevant conflicts of interests/financial disclosures This work was supported by the project Central European Institute of Technology 2020 (LQ1601) by the Ministry of Education, Youth and Sports of the Czech Republic; the EU Joint Programme – Neurodegenerative Disease Research (JPND) grant Pre‐clinical genotype‐phenotype Predictors of Alzheimer's disease and other dementias (APGeM); and the 15‐33854A grant from the Czech Ministry of Health. Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease.
Objectives: The objective of this study was to evaluate... Functional connectivity is abnormal in PD and in early Alzheimer's disease. The objective of this study was to evaluate resting-state striato-cortical... BACKGROUNDFunctional connectivity is abnormal in PD and in early Alzheimer's disease.OBJECTIVESThe objective of this study was to evaluate resting-state... |
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| SubjectTerms | Aged Aged, 80 and over Alzheimer Disease - complications Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiopathology cognition Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Connectome - methods Corpus Striatum - diagnostic imaging Corpus Striatum - physiopathology Executive Function - physiology Female Humans Magnetic Resonance Imaging Male Middle Aged Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - physiopathology Parkinson's disease resting state functional connectivity striatum |
| Title | Striato‐cortical connections in Parkinson's and Alzheimer's diseases: Relation to cognition |
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