Striato‐cortical connections in Parkinson's and Alzheimer's diseases: Relation to cognition
ABSTRACT Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting‐state striato‐cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mi...
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Published in | Movement disorders Vol. 32; no. 6; pp. 917 - 922 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2017
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Subjects | |
Online Access | Get full text |
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Summary: | ABSTRACT
Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease.
Objectives: The objective of this study was to evaluate resting‐state striato‐cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared.
Methods: Seed‐based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between‐group differences and clinical outcomes was assessed.
Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease.
Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. © 2017 International Parkinson and Movement Disorder Society |
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Bibliography: | Nothing to report. Relevant conflicts of interests/financial disclosures This work was supported by the project Central European Institute of Technology 2020 (LQ1601) by the Ministry of Education, Youth and Sports of the Czech Republic; the EU Joint Programme – Neurodegenerative Disease Research (JPND) grant Pre‐clinical genotype‐phenotype Predictors of Alzheimer's disease and other dementias (APGeM); and the 15‐33854A grant from the Czech Ministry of Health. Funding agencies ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0885-3185 1531-8257 |
DOI: | 10.1002/mds.26956 |