A single nucleotide polymorphism in BCAT1 gene is associated with type 2 diabetes mellitus

• Published in: Acta biochimica Polonica Vol. 69; no. 1; p. 19
• Main Authors: Alfaqih, Mahmoud A., Abu-Khdair, Zaina E., Khabour, Omar, Kheirallah, Khalid A., Khanfar, Mariam
• Format: Journal Article
• Language: English
• Published: Poland 21.12.2021
• Subjects: Case-Control Studies; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genotype; Humans; Obesity; Polymorphism, Single Nucleotide; Transaminases - genetics

The level of circulatory branched chain amino acids (BCAAs) is often increased in type 2 diabetes mellitus (T2DM). Catabolism of BCAAs involves a transamination reaction mediated by the branched chain amino acid aminotransferase (BCAT1) enzyme. Differences in the level of BCAT1 were found to be link...