Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 84; no. 17; pp. 2911 - 2925
• Main Authors: Menegollo, Michela, Bentham, Robert B, Henriques, Tiago, Ng, Seow Q, Ren, Ziyu, Esculier, Clarinde, Agarwal, Sia, Tong, Emily T Y, Lo, Clement, Ilangovan, Sanjana, Szabadkai, Zorka, Suman, Matteo, Patani, Neill, Ghanate, Avinash, Bryson, Kevin, Stein, Robert C, Yuneva, Mariia, Szabadkai, Gyorgy
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 04.09.2024
• Subjects: Breast Cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Computational Cancer Biology and Technology; Energy Metabolism - genetics; Female; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Genome Biology; Humans; Metabolism; Mitochondria - genetics; Mitochondria - metabolism; Multigene Family; Prognosis; Transcriptome

Adaptive metabolic switches are proposed to underlie conversions between cellular states during normal development as well as in cancer evolution. Metabolic adaptations represent important therapeutic targets in tumors, highlighting the need to characterize the full spectrum, characteristics, and re...