Formulation of DOX-dimer with bi-functionalized chitooligosaccharide for tumor-specific self-boosted drug release and synergistic chemo/chemodynamic therapy

• Published in: Carbohydrate polymers Vol. 320; p. 121210
• Main Authors: Xie, Pengwei, Liu, Peng
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.11.2023
• Subjects: Functionalized chitooligosaccharide; pH/ROS dual-triggered; ROS-activated DOX-based dimer; Self-boosted drug release; Synergistic chemo/chemodynamic therapy; Synergistic chemo/chemodynamic therapy; ROS-activated DOX-based dimer; Self-boosted drug release; pH/ROS dual-triggered; Functionalized chitooligosaccharide

The toxic side effects and possible drug resistance of the chemotherapeutics hinder their antitumor efficacy. Here, a pH/reactive oxygen species (ROS) dual-triggered nanodrug was developed for the tumor-specific self-boosted drug release and synergistic chemo/chemodynamic therapy, by formulating ROS...