Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism

Erythrocytes of patients with pseudohypoparathyroidism exhibit decreased activity of a membrane protein that is required for functional coupling of hormone receptors and catalytic adenylate cyclase. We observed decreased activity of this coupling protein in platelet extracts obtained from two pseudo...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 51; no. 5; p. 1202
Main Authors Farfel, Z, Bourne, H R
Format Journal Article
LanguageEnglish
Published United States 01.11.1980
Subjects
Adenylyl Cyclases - blood
Adult
Blood Platelets - drug effects
Blood Platelets - metabolism
Female
Humans
Hypothyroidism - blood
Kinetics
Male
Prostaglandins E - pharmacology
Pseudohypoparathyroidism - blood
Receptors, Cell Surface - metabolism
Reference Values
Sodium Fluoride - pharmacology
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Summary:Erythrocytes of patients with pseudohypoparathyroidism exhibit decreased activity of a membrane protein that is required for functional coupling of hormone receptors and catalytic adenylate cyclase. We observed decreased activity of this coupling protein in platelet extracts obtained from two pseudohypoparathyroid subjects, as compared with those of four normal control subjects. These findings support the hypothesis that generalized deficiency of this coupling protein is the primary biochemical defect of pseydohypoparathyroidism.
ISSN:0021-972X
1945-7197
DOI:10.1210/jcem-51-5-1202