Lack of a direct effect of 1,25-dihydroxycholecalciferol on parathyroid hormone secretion by normal bovine parathyroid glands

• Published in: Endocrinology (Philadelphia) Vol. 107; no. 2; p. 602
• Main Authors: Golden, P, Greenwalt, A, Martin, K, Bellorin-Font, E, Mazey, R, Klahr, S, Slatopolsky, E
• Format: Journal Article
• Language: English
• Published: United States 01.08.1980
• Subjects: Animals; Calcitriol; Calcium - pharmacology; Cattle; Dihydroxycholecalciferols - pharmacology; Hydroxycholecalciferols - pharmacology; In Vitro Techniques; Kinetics; Parathyroid Glands - drug effects; Parathyroid Glands - secretion; Parathyroid Hormone - secretion; Peptide Fragments - pharmacology

Because of differing reports of an effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on parathyroid hormone (PTH) secretion, the present studies were performed in vitro using bovine parathyroid gland slices and isolated parathyroid cells. Both COOH-terminal and NH2-terminal RIAs for PTH were employed...