Antepartum Treatment Without Early Cordocentesis for Standard-Risk Alloimmune Thrombocytopenia : A Randomized Controlled Trial

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 110; no. 2; pp. 249 - 255
• Main Authors: BERKOWITZ, Richard L, LESSER, Martin L, MCFARLAND, Janice G, WISSERT, Megan, PRIMIANI, Andrea, HUNG, Crystal, BUSSEL, James B
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 01.08.2007
• Subjects: Adult; Anti-Inflammatory Agents - administration & dosage; Antigens, Human Platelet - immunology; Biological and medical sciences; Cordocentesis - adverse effects; Drug Combinations; Female; Fetal Blood - cytology; Fetal Blood - drug effects; Gynecology. Andrology. Obstetrics; Hematologic and hematopoietic diseases; Humans; Immunoglobulins, Intravenous - administration & dosage; Intracranial Hemorrhages - prevention & control; Medical sciences; Platelet Count; Platelet diseases and coagulopathies; Prednisone - administration & dosage; Pregnancy; Pregnancy Complications, Hematologic - drug therapy; Pregnancy Complications, Hematologic - immunology; Pregnancy Outcome; Prospective Studies; Thrombocytopenia - drug therapy; Thrombocytopenia - immunology; Thrombocytopenia; Gynecology; Cordocentesis; Risk; Hemopathy; Obstetrics; Randomized controlled trial; Standards; Isoimmunization; Platelet; Prenatal diagnosis; Treatment; Risk factor; Early

To evaluate the effectiveness and safety of two antenatal treatment regimens designed to optimally protect fetuses against intracranial hemorrhage resulting from alloimmune thrombocytopenia while minimizing the risks associated with fetal blood sampling. The study was limited to "standard-risk&...