ATP-Dependent Transport of Leukotrienes B4 and C4 by the Multidrug Resistance Protein ABCC4 (MRP4)

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 324; no. 1; pp. 86 - 94
• Main Authors: Rius, Maria, Hummel-Eisenbeiss, Johanna, Keppler, Dietrich
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2008; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Adenosine Triphosphate - metabolism; Animals; Blood Platelets - metabolism; Cell Line; Cell Membrane - metabolism; Cells, Cultured; Cricetinae; Cricetulus; Erythrocytes - metabolism; Glutathione - pharmacology; Humans; Leukocytes, Mononuclear - metabolism; Leukotriene B4 - metabolism; Leukotriene C4 - metabolism; Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; Neutrophils - metabolism; Recombinant Proteins - metabolism; Transport Vesicles - metabolism

The proinflammatory mediators leukotriene (LT) B4 and LTC4 must be transported out of cells before they can interact with LT receptors. Previously, we identified the multidrug resistance protein ABCC1 (MRP1) as an efflux pump for LTC4. However, the molecular basis for the efflux of LTB4 was unknown....