Clinically relevant humanized mouse models of metastatic prostate cancer facilitate therapeutic evaluation

• Published in: Molecular cancer research Vol. 22; no. 9; pp. 826 - 839
• Main Authors: Kostlan, Raymond Joseph, Phoenix, John T, Budreika, Audris, Ferrari, Marina G, Khurana, Neetika, Choi, Jae Eun, Juckette, Kristin, Mahapatra, Somnath, McCollum, Brooke L, Moskal, Russell, Mannan, Rahul, Qiao, Yuanyuan, Vander Griend, Donald J, Chinnaiyan, Arul M, Kregel, Steven
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 04.09.2024
• Subjects: Cancer Research Resources; Drug Mechanisms; Endocrine-related Cancers; Genitourinary Cancers; Immunology; Immunotherapy; Preclinical Models; Progression, Invasion & Metastasis

There is tremendous need for improved prostate cancer (PCa) models. The mouse prostate is anatomically and developmentally different from the human prostate and does not spontaneously form tumors. Genetically engineered mouse models lack the heterogeneity of human cancer and rarely establish metasta...