Detection of acute radiation damage to the spleen in mice by using fluorine-19 MR imaging

• Published in: American journal of roentgenology (1976) Vol. 151; no. 3; pp. 477 - 480
• Main Authors: Ratner, AV, Muller, HH, Bradley-Simpson, B, Hirst, D, Pitts, W, Young, SW
• Format: Journal Article
• Language: English
• Published: Leesburg, VA Am Roentgen Ray Soc 01.09.1988; American Roentgen Ray Society
• Subjects: Abdomen; Acute Disease; Animals; Biological and medical sciences; Fluorine; Fluorocarbons; Gastroenterology. Liver. Pancreas. Abdomen; Liver - pathology; Magnetic Resonance Imaging - methods; Medical sciences; Mice; Mice, Inbred C3H; Other diseases. Semiology; Radiation Injuries, Experimental - diagnosis; Spleen - pathology; Splenic Diseases - diagnosis; Spleen; Acute; Rodentia; Radiotherapy; Nuclear magnetic resonance imaging; Vertebrata; Experimental disease; Mammalia; Mouse; Radiation injury; Digestive diseases; Complication; Tumor

Previous work in our laboratory has shown that an IV-administered emulsion of perfluorooctylbromide, an agent known to localize in functioning macrophages in the reticuloendothelial system, can be detected in the liver and spleen by using fluorine-19 (19F) MR imaging. In mice that have received a si...