Aptamer-based isolation and subsequent imaging of mesenchymal stem cells in ischemic myocard by magnetic resonance imaging

• Published in: RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren Vol. 179; no. 10; p. 1009
• Main Authors: Schäfer, R, Wiskirchen, J, Guo, K, Neumann, B, Kehlbach, R, Pintaske, J, Voth, V, Walker, T, Scheule, A M, Greiner, T O, Hermanutz-Klein, U, Claussen, C D, Northoff, H, Ziemer, G, Wendel, H P
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2007
• Subjects: Animals; Aptamers, Nucleotide; Bone Marrow Cells; Cardiomyoplasty - methods; Cell Separation; Feasibility Studies; Fluorescent Dyes; Immunomagnetic Separation; Magnetic Resonance Imaging; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells - cytology; Myocardial Ischemia; Organic Chemicals; Staining and Labeling; Swine; Time Factors

Mesenchymal stem cells (MSC) seem to be a promising cell source for cellular cardiomyoplasty. We recently developed a new aptamer-based specific selection of MSC to provide "ready to transplant" cells directly after isolation. We evaluated MRI tracking of newly isolated and freshly transpl...