PM2.5 promotes platelet activation and thrombosis via ROS/MAPKs pathway-mediated mitochondrial dysfunction

• Published in: Environmental research Vol. 283; p. 122116
• Main Authors: Xie, Yuquan, Fan, Dongxia, Wu, Biao, Guo, Jianshu, Wang, Ge, Yu, Lu, Zhang, Chihang, Zhao, Jinzhuo, Zhang, Si
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2025
• Subjects: mt-COX1; Platelets; PM2.5; ROS; Thrombus; mt-COX1; Platelets; Thrombus; PM2.5; ROS

Particulate matter (PM2.5) has been identified as a significant risk factor for the development of cardiovascular disease. The current work combined a human panel study with animal experiments intended to investigate the effects of ambient PM2.5 on platelet function and tried to figure out the poten...