Ocular Mucin Gene Expression Levels as Biomarkers for the Diagnosis of Dry Eye Syndrome

• Published in: Investigative ophthalmology & visual science Vol. 52; no. 11; p. 8363
• Main Authors: Corrales, Rosa M., Narayanan, Srihari, Fernández, Itziar, Mayo, Agustín, Galarreta, David J., Fuentes-Páez, Graciana, Chaves, Felipe J., Herreras, José M., Calonge, Margarita
• Format: Journal Article
• Language: English
• Published: United States 28.10.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Conjunctiva - metabolism; Conjunctiva - pathology; Dry Eye Syndromes - diagnosis; Dry Eye Syndromes - genetics; Eye Proteins - genetics; Female; Gene Expression Regulation - physiology; Humans; Male; Middle Aged; Mucin 5AC - genetics; Mucin-1 - genetics; Mucin-2 - genetics; Mucin-4 - genetics; Mucins - genetics; Prospective Studies; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; Salivary Proteins and Peptides - genetics; Sensitivity and Specificity; Young Adult

To evaluate mRNA levels of the ocular mucins MUC1, MUC2, MUC4, MUC5AC, and MUC7 in conjunctival impression cytology samples from patients with moderate to severe dry eye syndrome (DES) compared with a population of healthy subjects; and to investigate the use of the levels of these mucin genes as bi...